FEBS Open Bio, EarlyView.TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo +11 more
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Impact of multiple consultations and switching in treatment-seeking in tuberculosis: Mathematical modelling and optimal control. [PDF]
PLoS OneSaini P, Bhattacharyya S.
europepmc +1 more source
Beyond p‐values: Assessing clinical significance in acupuncture research
Advanced Chinese Medicine, EarlyView.Abstract In acupuncture randomized controlled trials (RCTs), the proper interpretation of results requires a thorough understanding of key statistical concepts such as p‐value, effect size, and the minimal clinically important difference (MCID). This paper explores the relationships among these metrics and their implications for assessing the clinical ...
Changzhen Gong
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Discussion: “The Optimal Control of Some Attitude Control Systems for Different Performance Criteria” (Flugge-Lotz, I., and Marbach, H., 1963, ASME J. Basic Eng., 85, pp. 165–175) [PDF]
, 1963 Bernard Friedland, H. O. Ladd
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Optimal control analysis to reduce the health complexity of co-infection with COVID-19 and kidney disease. [PDF]
Sci RepHye MA, Biswas MHA, Uddin MF.
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Discontinuation of Immunotherapy in Patients With Relapsing Myelitis Without AQP4/MOG Antibodies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT This study assesses the outcomes of immunotherapy discontinuation in patients with relapsing seronegative idiopathic myelitis (SIM), a condition that remains uninvestigated due to its rarity. We reviewed records from 77 patients with relapsing SIM at the National Cancer Center of Korea, focusing on 11 who discontinued treatment after a median ...
Ki Hoon Kim +4 more
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Discussion: “Optimal Control Methods for On-Off Sampling Systems” (Nelson, W. L., 1962, ASME J. Basic Eng., 84, pp. 91–99) [PDF]
, 1962 C. Desoer, J. Wing
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Entropy Generation Optimization in Multidomain Systems: A Generalized Gouy-Stodola Theorem and Optimal Control. [PDF]
Entropy (Basel)Richter H, Fathizadeh M, Kaptain T.
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Dopaminergic medication and deep brain stimulation (DBS) improve motor symptoms in Parkinson's disease (PD), but levodopa response alone may not predict DBS outcomes. We retrospectively analyzed 19 PD patients undergoing levodopa challenges with and without prior transcranial direct current stimulation targeting a defined PD response network ...
Lukas L. Goede +3 more
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