Results 161 to 170 of about 4,114,836 (337)
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Vibration analysis and optimal design of tracked vehicle's seat suspension for improving combat efficiency. [PDF]
Le V +5 more
europepmc +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Study and Optimal Design of the Integrated 37° Unidirectional SV-EMAT for Rapid Rail Flaw Detection. [PDF]
Yuan W.
europepmc +1 more source
A Design of Optimal Deadbeat Controller for Multivariable System by Using Impulse Response
Hiroshi Murata, Setuo Sagara
openalex +2 more sources
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Numerical and experimental study on optimal design of rock bolts in single-lining support of expressway tunnel. [PDF]
Wu M, Jiang B, Hu X, Wu S.
europepmc +1 more source
A study on design of optimal location for renewable energy facility using GIS
Moon-Seon Jung +4 more
openalex +2 more sources

