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Characterization of Clinical Phenotype to Glial Fibrillary Acidic Protein Concentrations in Alexander Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the concentration of glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and plasma in Alexander disease (AxD) and whether GFAP levels are predictive of disease phenotypes. Methods CSF and plasma were collected (longitudinally when available) from AxD participants and non‐AxD controls.
Amy T. Waldman   +9 more
wiley   +1 more source

A Heart Rate Matched Patch for Mechano-Chemical Treatment of Myocardial Infarction: Optimal Design and Transspecies Application. [PDF]

open access: yesResearch (Wash D C)
Jia Y   +12 more
europepmc   +1 more source

Functionally Graded Materials and Structures: Unified Approach by Optimal Design, Metal Additive Manufacturing, and Image-Based Characterization. [PDF]

open access: yesMaterials (Basel)
Silva RF   +10 more
europepmc   +1 more source
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Optimal Supersaturated Designs

Journal of the American Statistical Association, 2014
We consider screening experiments where an investigator wishes to study many factors using fewer observations. Our focus is on experiments with two-level factors and a main effects model with intercept. Since the number of parameters is larger than the number of observations, traditional methods of inference and design are unavailable.
Jones, Bradley, Majumdar, Dibyen
openaire   +2 more sources

Optimal Auction Design [PDF]

open access: possibleMathematics of Operations Research, 1981
This paper considers the problem faced by a seller who has a single object to sell to one of several possible buyers, when the seller has imperfect information about how much the buyers might be willing to pay for the object. The seller's problem is to design an auction game which has a Nash equilibrium giving him the highest possible expected utility.
openaire   +3 more sources

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