Results 121 to 130 of about 45,611 (300)
Advanced Science, EarlyView.This study presents an intravesical delivery strategy of ferroptosis‐ and immunity‐inducing nanozyme‐loaded thermoresponsive hydrogels (FMCC@PNH) for enhanced bladder cancer therapy. Abstract Current intravesical therapies for bladder cancer after resection are limited by poor tissue penetration, off‐target effects, and insufficient efficacy.
Yongnan Jiang +11 more
wiley +1 more source
Logic‐Gated HSV‐TK/GCV Suicide Gene Circuit for Triple‐Negative Breast Cancer
Advanced Science, EarlyView.The BRAS comprises two modular genetic components driven by distinct tumor‐specific promoters and a failsafe layer with the NOT gate. This multi‐input logic gate circuit enables precise, specific expression of HSV‐TK in breast cancer cells with hardly expression in normal cell and effectively inhibits tumor growth in a triple‐negative breast cancer ...
Shasha Tang +10 more
wiley +1 more source
Optimal hedge ratio and hedging effectiveness of Turkish stock index futures
, 2021 Bu tezin amacı, İMKB-30 endeks vadeli işlem sözleşmelerine ait optimal korunma oranının çeşitli ekonometrik modeller uygulanarak tespit edilmesidir. Optimal korunma oranının hesaplanmasında, Doğrusal Regresyon modeli, Yöney Kendiylebağlaşım (VAR) modeli, Hata Düzeltme modeli (ECM), GARCH modeli ve Çok Değişkenli GARCH (M-GARCH) modeli kullanılmıştır ...
openaire +1 more source
Cross-Hedging Fishmeal: Exploring Corn and Soybean Meal Futures Contracts [PDF]
During 2006 the fishmeal price nearly doubled from $500MT to over $900MT. The objective of this research is to determine the optimal cross-hedge ratio between fishmeal and soybean meal and corn, and corresponding hedging weight between corn and soybean ...
Altman, Ira J. +3 more
core +1 more source
Advanced Science, EarlyView.This study introduces Cadict, an EGFR‐targeted nanodrug that co‐delivers cuproptosis and disulfidptosis inducers to overcome immune resistance. Cadict synergistically enhances tumor cytotoxicity and sensitizes cancers to ICIs by upregulating PD‐L1 via an Eif5b‐dependent translation mechanism, fostering a potent antitumor immune response and ...
Shaoqing Huang +12 more
wiley +1 more source
Pricing and Hedging Illiquid Energy Derivatives:an Application to the JCC Index [PDF]
In this paper we discuss a simple econometric strategy for pricing and hedging illiquid financial products, such as the Japanese crude oil cocktail (JCC) index, the most popular OTC energy derivative in Japan. First, we review the existing literature for
Elisa Scarpa, Matteo Manera
core
Risk management with default-risky forwards [PDF]
, 2008 This paper studies the impact of counter-party default risk of forward contracts on a firm's production and hedging decisions. Using a model of a risk-averse competitive firm under price uncertainty, it derives several fundamental results.
Korn, Olaf
core
Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Advanced Science, EarlyView.Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source
Willingness to Pay for Weather Derivatives by Australian Wheat Farmers [PDF]
A theoretical optimal hedging model is developed to determine potential demand from Australian farmers for a hedging tool to remove the economic consequences of climate related variability in wheat yield.
Byrnes, Joel +2 more
core +1 more source
Advanced Science, EarlyView.A pH/ROS‐dual‐responsive injectable hydrogel, formed by dynamic boronic ester and Schiff base crosslinking, co‐delivers enoblituzumab (B7‐H3 blocker) and Cl‐amidine (NETs suppressor). Via localized intratumoral delivery, it synergistically reprograms the immunosuppressive tumor microenvironment, overcomes T cell infiltration barriers, restores ...
Huan Li +12 more
wiley +1 more source