Results 41 to 50 of about 60,783 (290)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Dynamic Programming for an Optimal and Equitable Public Load Shedding Schedule
Croatian Operational Research Review, 2018 This paper provides a method for an optimal and equitable schedule of public load shedding on any time interval and any number of sectors. By combining dynamic programming and knapsack techniques, the method gives a schedule that iterates over particular
Babacar Mbaye Ndiaye +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Contingency-Constrained Unit Commitment with Post-Contingency Corrective Recourse
, 2014 We consider the problem of minimizing costs in the generation unit commitment problem, a cornerstone in electric power system operations, while enforcing an N-k-e reliability criterion. This reliability criterion is a generalization of the well-known $N$-
Chen, Richard Li-Yang +3 more
core +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Equity-aware Load Shedding Optimization
Load shedding is usually the last resort to balance generation and demand to maintain stable operation of the electric grid after major disturbances. Current load-shedding optimization practices focus mainly on the physical optimality of the network power flow.
Fang, Xin, Wang, Wenbo, Ding, Fei
openaire +2 more sources
Increasing security of supply by the use of a local power controller during large system disturbances [PDF]
, 2011 This paper describes intelligent ways in which distributed generation and local loads can be controlled during large system disturbances, using Local Power Controllers.
Bright, C. G. +3 more
core +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Decentralized Adaptive Under Frequency Load Shedding Scheme Based on Load Information
IEEE Access, 2019 The inertia of the power system changes when the generators in the system are disturbed or tripped. However, in some systems, there is no control center or communication device falling behind.
Peican He, Buying Wen, Huaiyuan Wang
doaj +1 more source