Results 41 to 50 of about 51,892 (262)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

An Optimization Scheduler in the Intranet Grid

open access: yes, 2016
Scheduling of processes is the basic task for a grid computing. This role is responsible for the allocation of time for computational agents. The calculation agent can include a wide range of devices, based on various types of computer systems. Is it possible to efficiently build a grid infrastructure in the company environment. The grid can be used in
Petr Lukasik, Martin Sysel
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Group Elevator Peak Scheduling Based on Robust Optimization Model

open access: yesAdvances in Electrical and Computer Engineering, 2013
Scheduling of Elevator Group Control System (EGCS) is a typical combinatorial optimization problem. Uncertain group scheduling under peak traffic flows has become a research focus and difficulty recently.
ZHANG, J., ZONG, Q.
doaj   +1 more source

Optimal outpatient appointment scheduling [PDF]

open access: yesHealth Care Management Science, 2007
In this paper optimal outpatient appointment scheduling is studied. A local search procedure is derived that converges to the optimal schedule with a weighted average of expected waiting times of patients, idle time of the doctor and tardiness (lateness) as objective. No-shows are allowed to happen. For certain combinations of parameters the well-known
Kaandorp, G., Koole, G.M.
openaire   +3 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Scheduling and control of high throughput screening systems with uncertainties and disturbances

open access: yesProduction and Manufacturing Research: An Open Access Journal, 2022
Based on the existing research work on the modeling and control of cyclically operated high-throughput screening systems, this paper presents the scheduling and control of high-throughput screening systems with uncertainties and disturbances.
Adetola Oke   +3 more
doaj   +1 more source

Scheduling Optimization of Linear Schedule with Constraint Programming

open access: yesComputer-Aided Civil and Infrastructure Engineering, 2018
In recent decades, construction project scheduling optimization has received extensive attention from the research community. However, the most commonly used scheduling approach, the critical path method, is often inapplicable to transportation-type linear projects.
Yuanjie Tang   +4 more
openaire   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Q-Learning Based Scheduling With Successive Interference Cancellation

open access: yesIEEE Access, 2020
This work studies the problem of scheduling using Q-learning, which is a reinforcement learning algorithm, in a Successive Interference Cancellation (SIC) - enabled wireless ad hoc network. Distributed Q-learning algorithm tries to find the best schedule
Ezgi Mete, Tolga Girici
doaj   +1 more source

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