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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov +2 more
wiley +1 more source

Application of hyperbolic partial differential equations in global optimal scheduling of UAV

Alexandria Engineering Journal, 2020
The global optimal scheduling of UAV (unmanned aerial vehicle) navigation channel is studied. Firstly, a multi-channel optimal scheduling mathematical model based on the HPDEs (hyperbolic partial differential equations) wave combination optimization is ...
Chong Tian, Kuo-Chi Chang, JinSong Chen
doaj +1 more source

Scheduling of Optimal DASH Streaming [PDF]

Proceedings of the International Conference on Internet of things and Cloud Computing, 2016
DASH (Dynamic Adaptive Streaming over HTTP) is now the most popular standard in video streaming. For supporting DASH video transmission over residential networks with small bandwidth variation (such as DSL based network for IPTV), we design an optimal transmission schedule, L2H.
Yu-Chi Liu +7 more
openaire +2 more sources

On Optimal Deadlock Detection Scheduling

IEEE Transactions on Computers, 2006
Deadlock detection scheduling is an important, yet often overlooked problem that can significantly affect the overall performance of deadlock handling. Excessive initiation of deadlock detection increases overall message usage, resulting in degraded system performance in the absence of deadlocks; while insufficient initiation of deadlock detection ...
Yibei Ling, Shigang Chen, Cho-Yu Jason Chiang +2 more
openaire +4 more sources

Optimization Pine Plantation Forest Management in Kediri FMU Regional Division II East Java

Jurnal Manajemen Hutan Tropika, 2017
Pine forest management today has not already reached its optimal state. The abnormal pine stand structure will cause a decrease in the production of pine resin.
Andrie Ridzki Prasetyo, Muhamad Buce Saleh, Sudarsono Soedomo +2 more
doaj +3 more sources

Improved genetic algorithm for job shop scheduling

Journal of Hebei University of Science and Technology, 2019
In order to obtain the optimal solution of genetic algorithm for job shop scheduling problem and improve the iteration speed of the algorithm, the improved method of genetic algorithm is studied.
Xianpeng ZHENG, Lei WANG
doaj +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source

Optimal scheduling of the stand‐alone micro grids considering the reliability cost

The Journal of Engineering
In order to prevent wastage of generated power of renewable resources, the energy storage systems can be utilized in the stand‐alone micro grids to store the excess produced power of the renewable generation units.
Ayoub Nargeszar +3 more
doaj +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source

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scheduling
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