Results 81 to 90 of about 369,776 (290)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Optimal Scheduling of Hydro‐Wind‐Photovoltaic Complementary System Based on Reinforcement Learning‐Proximal Policy Optimization

The Journal of Engineering
The power output of wind power and photovoltaic (PV) features strong stochastic and intermittent characteristics, which increases the difficulty of economic scheduling for the power grid.
Xiaokun Liu, Jian Su, Le Li, Yuanyuan Han, Hongwei Ran, Yuan Wang   +5 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Fuzzy Byproduct Gas Scheduling in the Steel Plant Considering Uncertainty and Risk Analysis

Energies, 2018
In the iron and steel enterprises, efficient utilization of byproduct gas is of great significance for energy conservation and emission reduction. This work presents a fuzzy optimal scheduling model for byproduct gas system.
Xueying Sun, Zhuo Wang, Jingtao Hu
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Improved genetic algorithm for job shop scheduling

Journal of Hebei University of Science and Technology, 2019
In order to obtain the optimal solution of genetic algorithm for job shop scheduling problem and improve the iteration speed of the algorithm, the improved method of genetic algorithm is studied.
Xianpeng ZHENG, Lei WANG
doaj   +1 more source

Multi-Objective Optimal Operation for Steam Power Scheduling Based on Economic and Exergetic Analysis

Energies, 2020
Steam supply scheduling (SSS) plays an important role in providing uninterrupted reliable energy to meet the heat and electricity demand in both the industrial and residential sectors.
Yu Huang, Weizhen Hou, Yiran Huang, Jiayu Li, Qixian Li, Dongfeng Wang, Yan Zhang   +6 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Experimental Analysis of Algorithms for Coflow Scheduling

, 2016
Modern data centers face new scheduling challenges in optimizing job-level performance objectives, where a significant challenge is the scheduling of highly parallel data flows with a common performance goal (e.g., the shuffle operations in MapReduce ...
CA Phillips, H Ballani, JY Leung, LA Hall, M Alizadeh, M Chowdhury, M Pinedo, M Skutella   +7 more
core   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source