Kinetic Gas Hydrate Inhibition by Alternating Dipeptoids with Optimal Size and Shape N-Substituents. [PDF]
Kelland MA +3 more
europepmc +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
The feasibility and accuracy of the method for selecting the optimal size of double-lumen tube in thoracic surgery: a prospective, randomized controlled trial. [PDF]
Cui G, Zhao L, Chi C, Liang S, Liu Z.
europepmc +1 more source
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
Corrigendum to "The optimal size of screw for using cement-screw technique to repair tibial defect in total knee arthroplasty: A finite element analysis" [Heliyon Volume <b>9</b>, Issue 3, March 2023, Article e14182]. [PDF]
Ma J, Xu C, Zhao G, Xiao L, Wang J.
europepmc +1 more source
Defining the Optimal Size of Medical Laboratories at the Primary Level of Health Care with Data Envelopment Analysis: Defining the Efficiency of Medical Laboratories. [PDF]
Lamovsek N, Klun M, Skitek M, Bencina J.
europepmc +1 more source
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef +2 more
wiley +1 more source
Optimal size and PEG coating of gold nanoparticles for prolonged blood circulation: a statistical analysis of published data. [PDF]
Nevozhay D, Rauch R, Wang Z, Sokolov KV.
europepmc +1 more source
Efficiency and optimal size of hospitals: Results of a systematic search. [PDF]
Giancotti M, Guglielmo A, Mauro M.
europepmc +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source

