Results 81 to 90 of about 19,752 (264)
Staff sizing as a mechanism of efficiency: An application of a non-parametric method
Cogent Business & Management, 2018 The concept of staff sizing aims to estimate or determine the ideal or optimal number of people needed to perform some organizational activities, which can be considered as a trend.
Raissa Damasceno Cunha +3 more
doaj +1 more source
P.Size: a sizing aid for optimized designs
Proceedings EURO-DAC '92: European Design Automation Conference, 2003 Transistor sizing at layout level is necessary to improve the overall performance of integrated circuits. The authors present the definition and the validation of a sizing aid, P.Size, integrated in a flexible cell generator. Based on a local optimization defined through an explicit formulation of delays, this sizing aid can be used to optimize real ...
Nadine Azémard +2 more
openaire +2 more sources
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Firefly Algorithm: Minimizing Cost on Single-Level Lot-Sizing Problem
Journal of Computing Research and Innovation, 2018 Nowadays, the industrial company plays a very important role to our country. However, the manufacturer industry has big issues in the production planning which called planning horizon where, the lot-sizing problem is one of the most important issues in ...
Siti Hafawati Jamaluddin +3 more
doaj
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Pareto Optimal Coalitions of Fixed Size
Journal of Mechanism and Institution Design, 2019 We tackle the problem of partitioning players into groups of fixed size, such as allocating eligible students to shared dormitory rooms. Each student submits preferences over the other individual students. We study several settings, which differ in the size of the rooms to be filled, the orderedness or completeness of the preferences, and the way of ...
Cseh, Ágnes +2 more
openaire +6 more sources
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
, 1987 A method for structural member sizing optimization to be used for designing planar frames is presented. The procedure is based on the Augmented Lagrangian Multiplier method. The algorithm includes the displacements as state variables and consequently combines the analysis and the search for the optimal section properties into a single step.
Alfredo Soeiro, M. Hoit
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Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source