Results 41 to 50 of about 342,776 (277)
Optimizing stop naturalness [PDF]
Physical Review D, 2012 In supersymmetric models a large average stop mass $M_S$ is well known to both boost the lightest Higgs boson mass $m_{h}$ and also make radiative electroweak symmetry breaking unnaturally tuned. The case of `maximal mixing', where the stop trilinear mixing term $A_t$ is set to give $A_t^2/M_S^2 = 6$, allows the stops to be as light as possible for a ...
openaire +2 more sources
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Optimal stopping in a general framework [PDF]
, 2012 We study the optimal stopping time problem $v(S)={\rm ess}\sup_{\theta \geq S} E[\phi(\theta)|\mathcal {F}_S]$, for any stopping time $S$, where the reward is given by a family $(\phi(\theta),\theta\in\mathcal{T}_0)$ \emph{of non negative random ...
Kobylanski, Magdalena +1 more
core +3 more sources
Graph Planning with Expected Finite Horizon
, 2018 Graph planning gives rise to fundamental algorithmic questions such as shortest path, traveling salesman problem, etc. A classical problem in discrete planning is to consider a weighted graph and construct a path that maximizes the sum of weights for a ...
Chatterjee, Krishnendu, Doyen, Laurent
core +1 more source
Intrusion Prevention Through Optimal Stopping
IEEE Transactions on Network and Service Management, 2022 We study automated intrusion prevention using reinforcement learning. Following a novel approach, we formulate the problem of intrusion prevention as an (optimal) multiple stopping problem. This formulation gives us insight into the structure of optimal policies, which we show to have threshold properties.
Kim Hammar, Rolf Stadler
openaire +2 more sources
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Optimal futility stopping boundaries for binary endpoints
BMC Medical Research MethodologyBackground Group sequential designs incorporating the option to stop for futility at the time point of an interim analysis can save time and resources.
Michaela Maria Freitag +2 more
doaj +1 more source
Stopping Set Distributions of Some Linear Codes [PDF]
, 2010 Stopping sets and stopping set distribution of an low-density parity-check code are used to determine the performance of this code under iterative decoding over a binary erasure channel (BEC).
Fu, Fang-Wei, Jiang, Yong, Xia, Shu-Tao
core
Optimal Stopping Under Probability Distortion [PDF]
SSRN Electronic Journal, 2011 Published in at http://dx.doi.org/10.1214/11-AAP838 the Annals of Applied Probability (http://www.imstat.org/aap/) by the Institute of Mathematical Statistics (http://www.imstat.org)
Xu, Z, Zhou, XY
openaire +4 more sources
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source