Results 131 to 140 of about 22,496 (241)

A shared speed encoding model for running and backing away behaviours in segregated neural circuits. [PDF]

Nat Commun
Chen J, Li H, Lian N, Yao L, Huang Y, Yin P, Xu Z, Zeng Y, Liu J, Fu M, Qin X, Ji X, Tan J, Xiao Z, Zhong W.   +14 more
europepmc   +1 more source

Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses

Advanced Science, EarlyView.
ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti, Giovanna Coceano, Mariline Mendes Silva, Jonatan Alvelid, Chiara Sgattoni, Andrea Volpato, Lea Rems, Luciano A. Masullo, Eduard M. Unterauer, Rafal Kowalewski, Lucie Delemotte, Erdinc Sezgin, Ralf Jungmann, Ilaria Testa   +13 more
wiley   +1 more source

Benefits and harms of lung cancer screening strategies in Argentina: a modeling study. [PDF]

Lancet Reg Health Am
Salgado MV, Cao P, Jeon J, Boyeras I, Mejia R, Meza R.   +5 more
europepmc   +1 more source

Carboranyl‐Curcuminoids for the Neutron Capture‐Based Treatment of Amyloid Aggregates in Alzheimer's Disease

Advanced Science, EarlyView.
The 10B‐enriched monocarbonyl analog of curcumin (BMAC) 10B‐9 enables site‐specific Boron Neutron Capture Therapy (BNCT) on amyloid‐β (Aβ) fibrils. Neutron irradiation induces histidine oxidation and fibril destabilization, as revealed by 1H‐NMR and FESEM analyses.
Sebastiano Micocci, Stefano Parisotto, Diego Alberti, Alberto Lanfranco, Valeria Bitonto, Polyssena Renzi, Martina Salmi, Andrea Magnani, Federica Dal Bello, Katiuscia Pagano, Laura Ragona, Nicoletta Protti, Annamaria Deagostino, Simonetta Geninatti Crich   +13 more
wiley   +1 more source

A cross-entropy method optimal stopping problems

, 2017
Empirical thesis.Bibliography: pages 57-631. Introduction -- 2. Literature review -- 3. Theory and methodology -- 4. Simulation study -- 5. Discussion and future research.There are frequent situations when observations are recorded consecutively over a ...
Kularatne, Thilini Dulanjali
core  

DIPLI: deep image prior lucky imaging for blind astronomical image restoration. [PDF]

Sci Rep
Singh S, Batsheva A, Rogov OY, Bouridane A.   +3 more
europepmc   +1 more source

DNA Replication Errors Drive Genome‐Wide Small Inverted Triplication Dynamics

Advanced Science, EarlyView.
This study provides insight into the dynamic equilibrium mechanism of a novel structural variant, small inverted triplication (SIT), which is generated by misalignment of the 3’ flap generated under DNA replication stress with palindromic sequence. Alternatively, the end sequence may fold back on itself to form an inverted fragment.
Yi Lei, Yu Zhou, Haitao Sun, Hang Yuan, Xinyu Pei, Jessica D. Hess, Yao Yan, Zunsong Hu, Mian Zhou, Zhaohui Gu, Li Zheng, Xiwei Wu, Binghui Shen   +12 more
wiley   +1 more source

Balancing the effective sample size in prior across different doses in the curve-free Bayesian decision-theoretic design for dose-finding trials. [PDF]

J Biopharm Stat
Xu J, Bi D, Fan SK, Lee BL, Lu Y.
europepmc   +1 more source

Stress History Establishes a Transient Tolerant State That Shapes Antibiotic Survival Upon Resuscitation

Advanced Science, EarlyView.
High‐throughput single‐cell analysis of resuscitating bacteria reveals a starvation‐history‐dependent transiently tolerant subpopulation that survives β$\beta$‐lactam exposure by temporarily reducing growth. Distinct from classical persisters, these actively growing yet dynamically modulated cells dominate survival across clinically relevant antibiotic
Kieran Abbott, Georgeos Hardo, Ruizhe Li, Jack Bradley, Ashraf Zarkan, Somenath Bakshi   +5 more
wiley   +1 more source

Hydraulic Seal Wear Classification by Fine-Tuning a Transformer-Based Audio Model Using Acoustic Emission. [PDF]

Sensors (Basel)
Svendsen LM, Shanbhag VV, Schlanbusch R.
europepmc   +1 more source