Results 21 to 30 of about 671,217 (256)

Setting Priorities for Innovation Policy and Evaluating Their Performance: Evidence from Europe and Lessons for Ukraine

Foresight and STI Governance, 2012
Setting priorities for supporting prospective technologies and activities is a key issue for science, technology and innovation (STI) policy. The general principles of priority-setting practices vary significantly across countries in terms of process ...
Gudrun Rumpf
doaj   +1 more source

Regional competitiveness in the context of “New industrial policy” – the case of Croatia [PDF]

Zbornik radova Ekonomskog fakulteta u Rijeci : časopis za ekonomsku teoriju i praksu, 2017
The purpose of this paper is to do research on regional conditions that are most conducive to maximising the positive effects of the implementation of “New industrial policy” (policy based on Smart specialisation strategy) to regional competitiveness ...
Katarina Bačić, Zoran Aralica
doaj   +1 more source

Technology persistence and monetary policy [PDF]

, 2012
In this paper, by using several statistical tools, we provide evidence of increased persistence of the U.S. total factor productivity. In a forward-looking model, agentsí optimal behavior depends on the autocorrelation structure of the exogenous shocks.
Pancrazi, Roberto, Vukotić, Marija
core   +1 more source

Defining Roles in Pediatric Palliative Care: Perspectives From Oncology and Palliative Care Teams

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Early integration of pediatric palliative care (PPC) is associated with improved symptom management, quality of life, and healthcare utilization for children with cancer. Despite this, variation persists in how PPC is understood, operationalized, and integrated within pediatric oncology programs. In particular, ambiguity surrounding
Leeat Granek, Lori Wiener, Stephanie Veldhuijzen van Zanten, Donna Johnston, Fyeza Hasan, Adam Rapoport, Nathasha Datoo, Kimberley Widger, Sumit Gupta, Karen Fergus, Anthony K. C. Chan, Alisha Kassam, Emily McCullogh, Dave Lysecki   +13 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Deep Reinforcement Learning and Game Theory for Computation Offloading in Dynamic Edge Computing Markets

IEEE Access, 2021
As a promising paradigm, computation offloading technology can offload computing tasks to multi-access edge computing (MEC) servers, which is an appealing choice for resource-constrained terminal devices to reduce their computational effort. However, due
Shuyang Li, Xiaohui Hu, Yongwen Du
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Optimal digitalization and pricing decisions in a dual-channel agri-food supply chain under subsidy mechanisms: a decision analytic framework

Frontiers in Sustainable Food Systems
IntroductionDigital traceability is essential to ensure the transparency of the agricultural supply chain. However, manufacturers face a key strategic dilemma: the high initial investment cost hinders the investment in traceability, and multi-channel ...
Haiyan Zhong, Yin Xiao, Hong Huo
doaj   +1 more source

Intellectual Property Rights Policy, Competition and Innovation [PDF]

, 2011
To what extent and in what form should the intellectual property rights (IPR) of innovators be protected? Should a company with a large technology lead over its rivals receive the same IPR protection as a company with a more limited advantage?
Acemoglu, Aghion, Aghion, Aghion, Aghion, Aghion, Almeida, Arrow, Baye, Boldrin, Boldrin, Budd, Bureau of Economic Analysis, Choi, Daron Acemoglu, Fudenberg, Fullerton, Gallini, Gallini, Gilbert, Green, Grossman, Hall, Harris, Harris, Hopenhayn, Hopenhayn, Judd, Klemperer, Kortum, Kremer, Moscarini, Moser, National Science Foundation, O’Donoghue, Pakes, Reinganum, Reinganum, Romer, Scotchmer, Segal, Stokey, Tandon, Taylor, Tirole, Ufuk Akcigit   +45 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source