Results 41 to 50 of about 3,385,985 (242)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Towards optimal solar tracking: a dynamic programming approach [PDF]

, 2015
The power output of photovoltaic systems (PVS) increases with the use of effective and efficient solar tracking techniques. However, current techniques suffer from several drawbacks in their tracking policy: (i) they usually do not consider the ...
Chalkiadakis, Georgios, Panagopoulos, Athanasios Aris, Jennings, R. Nicholas   +2 more
core   +2 more sources

Optimal Winter and Summer Settings of Solar Photovoltaic Panels for Many Locations in the World

Tikrit Journal of Pure Science
An increasing interest in the use of solar energy to generate electricity for several applications has stimulated a need for studying optimal settings of photovoltaic panels. The photovoltaic panel performance is highly affected by its direction and its
Dr. Aqeel Salih
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Determination the optimal tilt and azimuth angle of photovoltaic system for maximum energy in Bucharest region, Romania - Case Study

E3S Web of Conferences, 2019
This study was conducted to evaluate the feasibility of installing a photovoltaic system for supplying the electric load of an environmental institute and to determinate the optimal tilt and azimuth angle of an 100 kW photovoltaic power plant located on ...
Mitiu Mihaela Andreea, Olteanu Marius Viorel, Deak Gyorgy, Raischi Natalia Simona, Cociorva Danut   +4 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Dynamics of tilt-based browsing on mobile devices [PDF]

, 2007
A tilt-controlled photo browsing method for small mobile devices is presented. The implementation uses continuous inputs from an accelerometer, and a multimodal (visual, audio and vibrotactile) display coupled with the states of this model.
Choi, C., Changkyu Choi, Sung-Jung Cho, Choi, Changkyu, Yeun-Bae Kim, Cho, S.J., Cho, Sung-Jung, Kwanghyeon Lee, Sung, Y., Murray-Smith, Roderick, Younghoon Sung, Kim, Y.B., Sung, Younghoon, Kim, Yeun-Bae, Lee, K., Murray-Smith, R., Lee, Kwanghyeon, Roderick Murray-Smith   +17 more
core   +2 more sources

Performance Characteristics of Photovoltaic Modules at Optimal Tilt Angle with Varying Shading Conditions: Embu County, Kenya Case Study [PDF]

Journal of Renewable Energy and Environment
Photovoltaic (PV) modules are widely used technologies for converting solar radiation directly into electrical energy. This study investigated the performance characteristics of PV modules under varying shading conditions and tilt angles.
Martin Ntoruru, Millien Kawira, Ali Halake, Jackson Wachira   +3 more
doaj   +1 more source