Results 121 to 130 of about 667,528 (289)

On the Economic Order Quantity Model With Transportation Costs [PDF]

We consider an economic order quantity type model with unit out-of-pocket holding costs, unitopportunity costs of holding, fixed ordering costs and general transportation costs.
Birbil, S.I., Bulbul, K., Frenk, J.B.G., Mulder, H.M.   +3 more
core   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Searching for optimal routes for mixed road-rail freight transportation [PDF]

MATEC Web of Conferences
The main direction for improving the efficiency of cargo transportation is the implementation of combined road-rail transportation. The difficulty in of solving this problem arises from the various conditions that occur when transporting goods by ...
Gera Bohdan, Hermaniuk Yuliia, Fedun Taras   +2 more
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Feasibility of the transportation options of renewable hydrogen for moderate distances: Insights from a remote production in Finland

Energy Conversion and Management: X
Renewable hydrogen production resources are frequently distant from the users, creating a need for transportation. The purpose of this study is to compare the economics of different transportation options for moderate distances (∼200 km).
Satu Lipiäinen, Esa Vakkilainen
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

The maximum range method for finding initial basic feasible solution for transportation problems

Results in Control and Optimization
The transportation problem is an essential branch of mathematics that industries use to minimize costs. The transportation problem is an optimization technique suitably modeled using linear programming. To obtain an optimal solution to the transportation
Fredrick Asenso Wireko, Ignatius Dennis Kwesi Mensah, Emmanuel Nii Apai Aborhey, Samuel Adu Appiah, Charles Sebil, Joseph Ackora-Prah   +5 more
doaj   +1 more source

Knowledge Spillovers and TFP Growth Rates [PDF]

In this paper I calibrate unobserved labor-generated knowledge spillovers within and between six large macroeconomic sectors covering the U.S. civilian economy from 1948 to 1991.
Nuria Quella
core