Results 41 to 50 of about 2,528,480 (312)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman +9 more
wiley +1 more source
Abstract and Applied Analysis, 2014 The present paper deals with the necessary optimality condition for a class of distributed parameter systems in which the system is modeled in one-space dimension by a hyperbolic partial differential equation subject to the damping and mixed constraints ...
Ismail Kucuk, Kenan Yildirim
doaj +1 more source
Exact Optimality of Balanced Designs for Minimum Norm Quadratic Unbiased Estimation of Variance Components in one-way Classified data [PDF]
The Egyptian Statistical Journal, 2004 This paper develops an exact theory for the optimality of balanced designs under minimum norm quadratic unbiased estimation of variances components in one-way classified data.
Mohamed Mohamed El-Abd
doaj +1 more source
Optimal Control Problems Involving Combined Fractional Operators with General Analytic Kernels
Mathematics, 2021 Fractional optimal control problems via a wide class of fractional operators with a general analytic kernel are introduced. Necessary optimality conditions of Pontryagin type for the considered problem are obtained after proving a Gronwall type ...
Faïçal Ndaïrou, Delfim F. M. Torres
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Reduced bone mineral density (BMD) has been reported in survivors of childhood and young adult acute lymphoblastic leukaemia (ALL); however, data from cohorts treated with contemporary protocols and including matched controls remain limited.
Karen Schow Jensen +10 more
wiley +1 more source
Bilevel programs with extremal value function: global optimality
International Journal of Mathematics and Mathematical Sciences, 2005 For a bilevel program with extremal value function, a necessary and sufficient condition for global optimality is given, which reduces the bilevel program to a max-min problem with linked constraints. Also, for the case where the extremal value function
Abdelmalek Aboussoror +2 more
doaj +1 more source
Identifying Patterns of Hospitalizations Among Childhood Cancer Survivors: A Population‐Based Study
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Childhood cancer survivors (CCSs) experience more hospitalizations than the general population. We aimed to identify distinct hospitalization patterns among Queensland CCSs and the associated characteristics. Methods Cases (aged ≤14 years) diagnosed between 1995 and 2019 while residents of Queensland were identified through the ...
Hai Pham +7 more
wiley +1 more source
Bilevel Optimization by Conditional Bayesian Optimization
Bilevel optimization problems have two decision-makers: a leader and a follower (sometimes more than one of either, or both). The leader must solve a constrained optimization problem in which some decisions are made by the follower. These problems are much harder to solve than those with a single decision-maker, and efficient optimal algorithms are ...
Vedat Dogan, Steven D. Prestwich
openaire +2 more sources
Information Processing in the Brain as Optimal Entropy Transport: A Theoretical Approach
Entropy, 2020 We consider brain activity from an information theoretic perspective. We analyze the information processing in the brain, considering the optimality of Shannon entropy transport using the Monge–Kantorovich framework.
Carlos Islas +2 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Febrile neutropenia (FN) is a frequent and serious complication in children receiving cancer therapy. Standardizing FN management across Asia is challenging due to variable healthcare infrastructure, diagnostic capacity, and infection patterns; however, it could improve resource use and patient outcomes.
Joliza Patricia Cañeba +29 more
wiley +1 more source