Results 91 to 100 of about 933,480 (358)

Development of an ethical framework for the use of social robots in the care of individuals with major neurocognitive disorders: a qualitative study

BMC Geriatrics
Background Despite the growing use of social robots in geriatric care, there is a lack of standardized ethical guidelines to inform and guide professionals in their implementation.
Caitlin Ware, Anne-Sophie Rigaud, Lauriane Blavette, Souad Damnée, Sebastien Dacunha, Hermine Lenoir, Matthieu Piccoli, Victoria Cristancho-Lacroix, Maribel Pino   +8 more
doaj   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Support Vector Machine Regression for Calibration Transfer between Electronic Noses Dedicated to Air Pollution Monitoring

Sensors, 2018
Recently, the emergence of low-cost sensors have allowed electronic noses to be considered for densifying the actual air pollution monitoring networks in urban areas.
Rachid Laref, Etienne Losson, Alexandre Sava, Maryam Siadat   +3 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Diagnostics-linked Antimicrobial Surveillance: A Route to Patient-Centred Microbiology Diagnostics?

International Journal of Infectious Diseases
Introduction: Microbiology diagnostics are widely recognised as an important tool in the fight against antimicrobial resistance (AMR), due to their ability to provide information to clinicians to inform antimicrobial treatment.
Dr Alex Howard, Dr Charlotte Brookfield, Dr Conor Rosato, Dr Anoop Velluva, Dr Alessandro Gerada, Professor William Hope   +5 more
doaj   +1 more source

BluePyOpt: Leveraging open source software and cloud infrastructure to optimise model parameters in neuroscience

, 2016
At many scales in neuroscience, appropriate mathematical models take the form of complex dynamical systems. Parametrising such models to conform to the multitude of available experimental constraints is a global nonlinear optimisation problem with a ...
Chindemi, Giuseppe, Courcol, Jean-Denis, Gevaert, Michael, Markram, Henry, Muller, Eilif, Rössert, Christian, Schürmann, Felix, Segev, Idan, Van Geit, Werner   +8 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Long-term machine perfusion of human split livers: a new model for regenerative and translational research

Nature Communications
Recent advances in machine perfusion have revolutionised the field of transplantation by prolonging preservation, permitting evaluation of viability prior to implant and rescue of discarded organs.
Ngee-Soon Lau, Geoffrey McCaughan, Mark Ly, Ken Liu, Michael Crawford, Carlo Pulitano   +5 more
doaj   +1 more source

Comparative Effects of Glenzocimab and Eptifibatide on Bleeding Severity in 2 Mouse Models of Intracranial Hemorrhage

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Antiplatelet drugs represent potential candidates for protecting the penumbral microcirculation during cerebral ischemia and improving the benefits of arterial recanalization in ischemic stroke.
Sébastien Dupont, Héloïse Lebas, Sabrina Mavouna, Eloïse Pascal, Astride Perrot, Adrien Cogo, Marie‐Charlotte Bourrienne, Carine Farkh, Mialitiana Solo Nomenjanahary, Véronique Ollivier, Fatima Zemali, Bernhard Nieswandt, Stéphane Loyau, Martine Jandrot‐Perrus, Eric Camerer, Jean‐Philippe Desilles, Mikael Mazighi, Yacine Boulaftali, Benoît Ho‐Tin‐Noé   +18 more
doaj   +1 more source