Results 101 to 110 of about 933,480 (358)

Practical Gauss-Newton Optimisation for Deep Learning [PDF]

, 2017
We present an efficient block-diagonal ap- proximation to the Gauss-Newton matrix for feedforward neural networks. Our result- ing algorithm is competitive against state- of-the-art first order optimisation methods, with sometimes significant improvement
Barber, David, Botev, Aleksandar, Ritter, Hippolyt   +2 more
core   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Adaptive intelligence: essential aspects [PDF]

, 2009
The article discusses essential aspects of Adaptive Intelligence. Experimental results on optimisation of global test functions by Free Search, Differential Evolution, and Particle Swarm Optimisation clarify how these methods can adapt to multi-modal ...
Penev, Kalin
core   +1 more source

Optimisation and Characterisation of Novel Angiotensin-Converting Enzyme Inhibitory Peptides Prepared by Double Enzymatic Hydrolysis from Agaricus bisporus Scraps [PDF]

, 2022
Rui Wang, Jianmin Yun, Shujuan Wu, Yang Bi, Fengyun Zhao   +4 more
openalex   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Methylomic signature of lithium response in bipolar disorder

European Psychiatry
Introduction Bipolar disorder (BD) is a chronic and severe psychiatric disorder, characterized by the alternance of episodes of (hypo)-mania and major depression.
C. Bourdon, C. Courtin, F. Bellivier, B. Etain, C. Marie-Claire   +4 more
doaj   +1 more source

Algorithms Applied to Global Optimisation – Visual Evaluation [PDF]

, 2012
Evaluation and assessment of various search and optimisation algorithms is subject of large research efforts. Particular interest of this study is global optimisation and presented approach is based on observation and visual evaluation of Real-Coded ...
Penev, Kalin
core   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Feasibility of serial measurement of nitrite for pharmacodynamic monitoring and precision prescribing in urinary tract infections

Communications Medicine
Background The ability to monitor host- and bacteria-specific biomarkers along with antimicrobial drug concentration at the site of infection offers potential for individualised approaches to antimicrobial therapy.
Ellen V. Stadler, Alison Holmes, Danny O’Hare, Mark Sutton, Colin Brown, Timothy M. Rawson   +5 more
doaj   +1 more source

Socio-demographic and clinical predictors of outcome to long-term treatment with lithium in bipolar disorders: a systematic review of the contemporary literature and recommendations from the ISBD/IGSLI Task Force on treatment with lithium

International Journal of Bipolar Disorders, 2020
Objective To identify possible socio-demographic and clinical factors associated with Good Outcome (GO) as compared with Poor Outcome (PO) in adult patients diagnosed with Bipolar Disorder (BD) who received long-term treatment with lithium.
Diane Grillault Laroche, Bruno Etain, Emanuel Severus, Jan Scott, Frank Bellivier, On behalf of the ISBD-IGSLI Joint Task Force on Lithium Treatment   +5 more
doaj   +1 more source