Results 121 to 130 of about 2,432,658 (317)

Nature-inspired Methods for Stochastic, Robust and Dynamic Optimization [PDF]

, 2018
Nature-inspired algorithms have a great popularity in the current scientific community, being the focused scope of many research contributions in the literature year by year. The rationale behind the acquired momentum by this broad family of methods lies

core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A Random-Key optimizer for combinatorial optimization [PDF]

Journal of Heuristics
54 pages, 16 figures, 8 ...
Antonio Augusto Chaves, Mauricio G. C. Resende, Martin J. A. Schuetz, John Kyle Brubaker, Helmut G. Katzgraber, Edilson Fernandes de Arruda, Ricardo M. A. Silva   +6 more
openaire   +2 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Plate Heat Exchanger Optimization Using Different Approximation Assisted Multiobjective Optimization Techniques [PDF]

, 2012
This paper presents a comparison between different multiobjective optimization approaches that can be used to optimize the design of thermal equipment. Plate heat exchanger is taken as case study to apply different optimization techniques.
Aute, Vikrant, Radermacher, Reinhard, Saleh, Khaled Hassan, Azarm, Shapour   +3 more
core   +1 more source

Triggered memory-based swarm optimization in dynamic environments [PDF]

, 2007
This is a post-print version of this article - Copyright @ 2007 Springer-VerlagIn recent years, there has been an increasing concern from the evolutionary computation community on dynamic optimization problems since many real-world optimization problems ...
Wang, H, Wang, X, Yang, S, Xingwei Wang (6019421), Hongfeng Wang, Shengxiang Yang, Dingwei Wang, Shengxiang Yang (7582940), Hongfeng Wang (1767415)   +8 more
core   +1 more source

Research on OPF Control of Three-Phase Four-Wire Low-Voltage Distribution Network considering Uncertainty

International Transactions on Electrical Energy Systems
As power systems become more complex and uncertain, low-voltage distribution networks face numerous challenges, including three-phase imbalances caused by asymmetrical loads and distributed energy resources.
Rui Wang, Xiaoqing Bai, Shengquan Huang, Shoupu Wei   +3 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Recent advances in surrogate-based optimization [PDF]

, 2009
The evaluation of aerospace designs is synonymous with the use of long running computationally intensive simulations. This fuels the desire to harness the efficiency of surrogate-based methods in aerospace design optimization.
Alexander I.J. Forrester, Andy J. Keane, Keane, Andy J., Forrester, Alexander I.J.   +3 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source