Results 101 to 110 of about 4,697,654 (286)

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

Research on OPF Control of Three-Phase Four-Wire Low-Voltage Distribution Network considering Uncertainty

open access: yesInternational Transactions on Electrical Energy Systems
As power systems become more complex and uncertain, low-voltage distribution networks face numerous challenges, including three-phase imbalances caused by asymmetrical loads and distributed energy resources.
Rui Wang   +3 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Calculation model for water influx and controlled reserves for CBM wells with high water yield

open access: yesPetroleum Research, 2018
Compared with conventional gas reservoir, percolation mechanism of coalbed methane (CBM) is completely different, it is remarkably affected by adsorption/desorption performance, pressure variation and coalbed characteristics.
Qing Feng   +5 more
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

ePyDGGA: automatic configuration for fitting epidemic curves

open access: yesScientific Reports
Many epidemiological models and algorithms are used to fit the parameters of a given epidemic curve. On many occasions, fitting algorithms are interleaved with the actual epidemic models, which yields combinations of model-parameters that are hard to ...
Josep Alòs   +5 more
doaj   +1 more source

A Survey of Methods for Gas-Lift Optimization

open access: yesModelling and Simulation in Engineering, 2012
This paper presents a survey of methods and techniques developed for the solution of the continuous gas-lift optimization problem over the last two decades. These range from isolated single-well analysis all the way to real-time multivariate optimization
Kashif Rashid   +2 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Securing federated learning: a defense strategy against targeted data poisoning attack

open access: yesDiscover Internet of Things
Ensuring the security and integrity of Federated Learning (FL) models against adversarial attacks is critical. Among these threats, targeted data poisoning attacks, particularly label flipping, pose a significant challenge by undermining model accuracy ...
Ansam Khraisat   +5 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

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