Results 61 to 70 of about 1,133,488 (268)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Use of Plackett–Burman Statistical Design to Study Factors Acting on the Nitric Acid Leaching of Rare Earth Elements from Moroccan Phosphogypsum

Journal of Chemistry
This work is an attempt to understand and optimize the rare earth elements leaching from Moroccan phosphogypsum using a nitric acid solution. The Plackett–Burman statistical design was used to identify the statistically significant factors responsible ...
Fatima Asafar, Marouane Amine, Abdelkader Outzourhit, Latifa Bilali, Mehdi Nadifiyine   +4 more
doaj   +1 more source

Optimal growth and Pareto optimality [PDF]

Journal of Mathematical Economics, 1991
Using the McKenzie-Montrucchio approach to optimal growth problems the authors show that in a stationary intertemporal economy with discrete infinite time span and recursive utilities for each of a finite numbers of agents, every Pareto optimum solution is a solution to a generalized McKenzie problem.
Dana Rose-anne, Le Van Cuong
openaire   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

When is Assortment Optimization Optimal?

Proceedings of the 23rd ACM Conference on Economics and Computation, 2022
Assortment optimization concerns the problem of selling items with fixed prices to a buyer who will purchase at most one. Typically, retailers select a subset of items, corresponding to an “assortment” of brands to carry, and make each selected item available for purchase at its brand-recommended price.
openaire   +4 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Measuring the Optimality of Hadoop Optimization

CoRR, 2013
In recent years, much research has focused on how to optimize Hadoop jobs. Their approaches are diverse, ranging from improving HDFS and Hadoop job scheduler to optimizing parameters in Hadoop configurations. Despite their success in improving the performance of Hadoop jobs, however, very little is known about the limit of their optimization ...
Woo-Cheol Kim, Changryong Baek, Dongwon Lee 0001   +2 more
openaire   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Normalization for FDS of Transformer Insulation Considering the Synergistic Effect Generated by Temperature and Moisture

IEEE Access, 2020
Frequency domain spectroscopy (FDS) technique is widely applied in the condition assessment of the oil-paper system in power transformers. However, the synergistic effect generated by moisture and temperature on the FDS data cannot be analyzed by the ...
Xianhao Fan, Shichang Yang, Lai Benhui, Jiefeng Liu, Yiyi Zhang, Zixiao Wang   +5 more
doaj   +1 more source