Results 141 to 150 of about 5,593,327 (347)

Combinations and Mixtures of Optimal Policies in Unichain Markov Decision Processes are Optimal [PDF]

open access: yesarXiv, 2005
We show that combinations of optimal (stationary) policies in unichain Markov decision processes are optimal. That is, let M be a unichain Markov decision process with state space S, action space A and policies \pi_j^*: S -> A (1\leq j\leq n) with optimal average infinite horizon reward.
arxiv  

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi   +26 more
wiley   +1 more source

Enhancing patient engagement in cancer research: a focus on patient‐centric approaches to scientific discovery

open access: yesMolecular Oncology, EarlyView.
Patient engagement involves actively including patients in healthcare decisions and research to ensure care and studies align with their needs. This approach improves outcomes, trust, and communication while fostering collaboration between patients and professionals.
Estela Cepeda   +3 more
wiley   +1 more source

Discrete Time Mean-Field Stochastic Linear-Quadratic Optimal Control Problems [PDF]

open access: yesarXiv, 2013
This paper first presents necessary and sufficient conditions for the solvability of discrete time, mean-field, stochastic linear-quadratic optimal control problems. Then, by introducing several sequences of bounded linear operators, the problem becomes an operator stochastic LQ problem, in which the optimal control is a linear state feedback ...
arxiv  

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

Securing federated learning: a defense strategy against targeted data poisoning attack

open access: yesDiscover Internet of Things
Ensuring the security and integrity of Federated Learning (FL) models against adversarial attacks is critical. Among these threats, targeted data poisoning attacks, particularly label flipping, pose a significant challenge by undermining model accuracy ...
Ansam Khraisat   +5 more
doaj   +1 more source

Continuity of the Value Function in Sparse Optimal Control [PDF]

open access: yesarXiv, 2014
We prove the continuity of the value function of the sparse optimal control problem. The sparse optimal control is a control whose support is minimum among all admissible controls. Under the normality assumption, it is known that a sparse optimal control is given by L^1 optimal control.
arxiv  

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