Results 141 to 150 of about 4,697,654 (286)

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Adversarial path planning for optimal CCTV surveillance: a case study on nuclear facility security optimization. [PDF]

Sci Rep
Salman AE, Shaaban N, Zidan WI, Saad MH.
europepmc   +1 more source

Optimizing Bayesian optimization

, 2019
We are concerned primarily with improving the practical applicability of Bayesian optimization. We make contributions in three key areas. We develop an intuitive online stopping criterion, allowing only as many steps as necessary to achieve the desired target to be taken.
openaire   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Antroquinonol A: Scalable Synthesis and Preclinical Biology of a Phase 2 Drug Candidate

ACS Central Science, 2015
Matthew T. Villaume, Eran Sella, Garrett Saul, Robert M. Borzilleri, Joseph Fargnoli, Kathy A. Johnston, Haiying Zhang, Mark P. Fereshteh, T. G. Murali Dhar, Phil S. Baran   +9 more
doaj   +1 more source

A hybrid pelican-GWO optimized fractional order PID controller for enhanced performance of hybrid active power filters. [PDF]

Sci Rep
Salah Eldeen RS, Elkoshairy AD, Mageed HMA, Ahmed AAEMS.   +3 more
europepmc   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

A two-stage multi-objective optimization framework for coordinated EV charging scheduling and reactive power dispatch. [PDF]

Sci Rep
Badr MS, Sharaf HM, Zobaa AM.
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Hybrid ML and metaheuristic optimization of slag-fly ash-gypsum modified solidified sludge for construction. [PDF]

Sci Rep
Azarkhosh H, Chen Y, Elias S.
europepmc   +1 more source