Results 121 to 130 of about 3,171,504 (308)
Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source
Scientific ReportsUtilization of optimization technique is a must in the design of contemporary antenna systems. Often, global search methods are necessary, which are associated with high computational costs when conducted at the level of full-wave electromagnetic (EM ...
Slawomir Koziel +1 more
doaj +1 more source
A Survey of Methods for Gas-Lift Optimization
Modelling and Simulation in Engineering, 2012 This paper presents a survey of methods and techniques developed for the solution of the continuous gas-lift optimization problem over the last two decades. These range from isolated single-well analysis all the way to real-time multivariate optimization
Kashif Rashid +2 more
doaj +1 more source
System Optimization Working Group Recommendations [PDF]
University of Minnesota. System Optimization Working Group. (2025). System Optimization Working Group Recommendations.
University of Minnesota. System Optimization Working Group
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Recent advances in surrogate-based optimization [PDF]
, 2009 The evaluation of aerospace designs is synonymous with the use of long running computationally intensive simulations. This fuels the desire to harness the efficiency of surrogate-based methods in aerospace design optimization.
Alexander I.J. Forrester +3 more
core +1 more source
Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease
FEBS Letters, EarlyView.Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Multi-Objective Optimization Technique Based on QUBO and an Ising Machine
IEEE AccessWith an increase in the complexity of society, solving multi-objective optimization problems (MOPs) has become crucial. In this study, we introduced a novel method called “quadratic unconstrained binary optimization based on the weighted normal ...
Hiroshi Ikeda, Takashi Yamazaki
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Application of robust and inverse optimization in transportation [PDF]
, 2010 Thesis (S.M.)--Massachusetts Institute of Technology, Computation for Design and Optimization Program, 2010.Cataloged from PDF version of thesis.Includes bibliographical references (p. 79-82).We study the use of inverse and robust optimization to address
Nguyen, Thai Dung
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