Results 111 to 120 of about 3,171,504 (308)

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Research on OPF Control of Three-Phase Four-Wire Low-Voltage Distribution Network considering Uncertainty

International Transactions on Electrical Energy Systems
As power systems become more complex and uncertain, low-voltage distribution networks face numerous challenges, including three-phase imbalances caused by asymmetrical loads and distributed energy resources.
Rui Wang, Xiaoqing Bai, Shengquan Huang, Shoupu Wei   +3 more
doaj   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

A Scalarizing One-Stage Algorithm for Efficient Multi-Objective Optimization [PDF]

, 2007
A novel kriging-assisted algorithm is proposed for computationally expensive multi-objective optimization problems, such as those which arise in electromagnetic design. The algorithm combines the multiple objectives into a single objective, which it then
Hawe, G. I., Sykulski, J. K., Hawe, G.I., Sykulski, J.K.   +3 more
core   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

ePyDGGA: automatic configuration for fitting epidemic curves

Scientific Reports
Many epidemiological models and algorithms are used to fit the parameters of a given epidemic curve. On many occasions, fitting algorithms are interleaved with the actual epidemic models, which yields combinations of model-parameters that are hard to ...
Josep Alòs, Carlos Ansótegui, Ivan Dotu, Manuel García-Herranz, Pol Pastells, Eduard Torres   +5 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

A Novel circRERE/miR-27a-3p/Caspase9 Signaling Axis Promotes Cardiomyocyte Apoptosis in Ischemic Myocardium: Insights from Epigallocatechin Gallate-Primed Exosomes

Cells
Acute myocardial infarction (AMI) causes high mortality, with cardiomyocyte apoptosis playing a critical role. Although circular RNAs modulate cardiac disorders, related mechanisms remain unclear.
Haiqi Li, Maoqin Wang, Yuxue Li, Xiaowen Gan, Ronggan Liang, Jun Lu, Jie Jian   +6 more
doaj   +1 more source

A Random-Key optimizer for combinatorial optimization [PDF]

Journal of Heuristics
54 pages, 16 figures, 8 ...
Antonio Augusto Chaves, Mauricio G. C. Resende, Martin J. A. Schuetz, John Kyle Brubaker, Helmut G. Katzgraber, Edilson Fernandes de Arruda, Ricardo M. A. Silva   +6 more
openaire   +3 more sources

Surrogate-based optimization of a BioMEMs microfluidic weir [PDF]

, 2008
Thesis (S.M.)--Massachusetts Institute of Technology, Computation for Design and Optimization Program, 2008.Includes bibliographical references (p. 127-130).BioMEM microfluidic weirs enable biologists to study biological processes at the cell level.
Ooi, Boon Hooi
core