Results 61 to 70 of about 2,985,285 (303)

Use of Plackett–Burman Statistical Design to Study Factors Acting on the Nitric Acid Leaching of Rare Earth Elements from Moroccan Phosphogypsum

Journal of Chemistry
This work is an attempt to understand and optimize the rare earth elements leaching from Moroccan phosphogypsum using a nitric acid solution. The Plackett–Burman statistical design was used to identify the statistically significant factors responsible ...
Fatima Asafar, Marouane Amine, Abdelkader Outzourhit, Latifa Bilali, Mehdi Nadifiyine   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Optimal growth and Pareto optimality [PDF]

Journal of Mathematical Economics, 1991
Using the McKenzie-Montrucchio approach to optimal growth problems the authors show that in a stationary intertemporal economy with discrete infinite time span and recursive utilities for each of a finite numbers of agents, every Pareto optimum solution is a solution to a generalized McKenzie problem.
Dana Rose-anne, Le Van Cuong
openaire   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Fast multi-swarm optimization for dynamic optimization problems [PDF]

, 2008
This article is posted here with permission of IEEE - Copyright @ 2008 IEEEIn the real world, many applications are non-stationary optimization problems. This requires that the optimization algorithms need to not only find the global optimal solution but
Yang, S, Li, Changhe, Shengxiang Yang, Yang, Shengxiang, Changhe Li, Li, C   +5 more
core   +1 more source

When is Assortment Optimization Optimal?

Proceedings of the 23rd ACM Conference on Economics and Computation, 2022
Assortment optimization concerns the problem of selling items with fixed prices to a buyer who will purchase at most one. Typically, retailers select a subset of items, corresponding to an “assortment” of brands to carry, and make each selected item available for purchase at its brand-recommended price.
openaire   +4 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Measuring the Optimality of Hadoop Optimization

CoRR, 2013
In recent years, much research has focused on how to optimize Hadoop jobs. Their approaches are diverse, ranging from improving HDFS and Hadoop job scheduler to optimizing parameters in Hadoop configurations. Despite their success in improving the performance of Hadoop jobs, however, very little is known about the limit of their optimization ...
Woo-Cheol Kim, Changryong Baek, Dongwon Lee 0001   +2 more
openaire   +2 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source