Results 91 to 100 of about 3,171,504 (308)
Journal of Research of the National Bureau of Standards, 1985 Most research and development projects require the optimization of a system response as a function of several experimental factors. Familiar chemical examples are the maximization of product yield as a function of reaction time and temperature; the maximization of analytical sensitivity of a wet chemical method as a function of reactant concentration ...
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, 2020 Multi-criteria optimization problems naturally arise in practice when there is no single criterion for measuring the quality of a feasible solution.
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Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
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IEEE Access, 2020 Frequency domain spectroscopy (FDS) technique is widely applied in the condition assessment of the oil-paper system in power transformers. However, the synergistic effect generated by moisture and temperature on the FDS data cannot be analyzed by the ...
Xianhao Fan +5 more
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Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
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Equating κ Maximum Degrees in Graphs without Short Cycles
Discussiones Mathematicae Graph Theory, 2020 For an integer k at least 2, and a graph G, let fk(G) be the minimum cardinality of a set X of vertices of G such that G − X has either k vertices of maximum degree or order less than k.
Fürst Maximilian +4 more
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FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
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IEEE Access, 2020 In recent decades, moisture evaluation of transformer oil-immersed cellulose insulation has been widely studied by using the frequency domain spectroscopy (FDS) technique.
Jiefeng Liu +4 more
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Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Data-Informed Decomposition for Localized Uncertainty Quantification of Dynamical Systems
Vibration, 2020 Industrial dynamical systems often exhibit multi-scale responses due to material heterogeneity and complex operation conditions. The smallest length-scale of the systems dynamics controls the numerical resolution required to resolve the embedded physics.
Waad Subber +4 more
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