Results 61 to 70 of about 1,195,450 (268)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Optimization

Journal of Research of the National Bureau of Standards, 1985
Most research and development projects require the optimization of a system response as a function of several experimental factors. Familiar chemical examples are the maximization of product yield as a function of reaction time and temperature; the maximization of analytical sensitivity of a wet chemical method as a function of reactant concentration ...
openaire   +2 more sources

Hepatitis C virus infection and Parkinson’s disease: insights from a joint sex-stratified BioOptimatics meta-analysis

Scientific Reports
Hepatitis C virus (HCV) infection poses a significant public health challenge and often leads to long-term health complications and even death. Parkinson’s disease (PD) is a progressive neurodegenerative disorder with a proposed viral etiology.
Isis Narváez-Bandera, Deiver Suárez-Gómez, Coral Del Mar Castro-Rivera, Alaina Camasta-Beníquez, Morelia Durán-Quintana, Mauricio Cabrera-Ríos, Clara E. Isaza   +6 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Normalization for FDS of Transformer Insulation Considering the Synergistic Effect Generated by Temperature and Moisture

IEEE Access, 2020
Frequency domain spectroscopy (FDS) technique is widely applied in the condition assessment of the oil-paper system in power transformers. However, the synergistic effect generated by moisture and temperature on the FDS data cannot be analyzed by the ...
Xianhao Fan, Shichang Yang, Lai Benhui, Jiefeng Liu, Yiyi Zhang, Zixiao Wang   +5 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Optimal Algorithms for Distributed Optimization

CoRR, 2017
In this paper, we study the optimal convergence rate for distributed convex optimization problems in networks. We model the communication restrictions imposed by the network as a set of affine constraints and provide optimal complexity bounds for four different setups, namely: the function $F(\xb) \triangleq \sum_{i=1}^{m}f_i(\xb)$ is strongly convex ...
César A. Uribe, Soomin Lee, Alexander V. Gasnikov, Angelia Nedic   +3 more
openaire   +3 more sources

Equating κ Maximum Degrees in Graphs without Short Cycles

Discussiones Mathematicae Graph Theory, 2020
For an integer k at least 2, and a graph G, let fk(G) be the minimum cardinality of a set X of vertices of G such that G − X has either k vertices of maximum degree or order less than k.
Fürst Maximilian, Gentner Michael, Jäger Simon, Rautenbach Dieter, Henning Michael A.   +4 more
doaj   +1 more source

A Novel Curve Database for Moisture Evaluation of Transformer Oil-Immersed Cellulose Insulation Using FDS and Exponential Decay Model

IEEE Access, 2020
In recent decades, moisture evaluation of transformer oil-immersed cellulose insulation has been widely studied by using the frequency domain spectroscopy (FDS) technique.
Jiefeng Liu, Zixiao Wang, Xianhao Fan, Yiyi Zhang, Jiaqi Wang   +4 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source