Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald +18 more
wiley +1 more source
Blindfolded Spider-man Optimization: A Single-Point Metaheuristics Suitable for Continuous and Discrete Spaces [PDF]
arXivIn this study, we introduce a new single point metaheuristic optimization approach suitable for both continuous and discrete domains. The proposed algorithm, entitled Blindfolded Spiderman Optimization, follows a piecewise linear search trajectory where each line segment considers a move to an improved solution point. The trajectory resembles spiderman
arxiv
FEBS Open Bio, EarlyView.This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi +2 more
wiley +1 more source
$C_{loc}^{1,1}$ optimal pairs in the dual optimal transport problem for a Lorentzian cost along displacement interpolations [PDF]
arXivWe consider the optimal transportation problem on a globally hyperbolic spacetime with a cost function $c$, which corresponds to the optimal transportation problem on a complete Riemannian manifold where the cost function is given by the squared Riemannian distance.
arxiv
Gradient and gravity center method in linear and nonlinear optimization [PDF]
, 1966 Klaus Lommatzsch
openalex +1 more source
Mapping Hsp104 interactions using cross‐linking mass spectrometry
FEBS Open Bio, Volume 15, Issue 6, Page 922-939, June 2025.This study examines how cross‐linking mass spectrometry can be utilized to analyze ATP‐induced conformational changes in Hsp104 and its interactions with substrates. We developed an analytical pipeline to distinguish between intra‐ and inter‐subunit contacts within the hexameric homo‐oligomer and discovered contacts between Hsp104 and a selected ...
Kinga Westphal +3 more
wiley +1 more source
Brief Mentions - G. Leitman, Topics in Optimization (Academic Press Inc., New York, 1967), xv+469 pp., $18.00. - H. J. Kushner, Stochastic Stability and Control (Academic Press Inc., New York, 1967), xi+161 pp. - A. Tuller, A Modern Introduction to Geometries (D. van Nostrand & Co., London, 1967), ix+201 pp., 60s. - A. W. Wallace, Differential Topology: First Steps (W. A. Benjamin Inc., New York, 1968), 130 pp., $9.50 cloth, $3.95 paper. - V. E. Benes, Mathematical Theory of Connecting … [PDF]
, 1969 openalex +1 more source
FEBS Open Bio, Volume 15, Issue 6, Page 898-905, June 2025.We introduce an immunohistochemistry method to measure autophagy flux, highlighting the active degradation and recycling of cellular waste. This cost‐effective approach uses tissue samples to track key markers like LC3 and SQSTM1, revealing how cells maintain health or respond to diseases such as cancer. It bridges the gap between research and clinical
Shahla Shojaei +6 more
wiley +1 more source