Results 171 to 180 of about 2,429,878 (317)

Antroquinonol A: Scalable Synthesis and Preclinical Biology of a Phase 2 Drug Candidate

ACS Central Science, 2015
Matthew T. Villaume, Eran Sella, Garrett Saul, Robert M. Borzilleri, Joseph Fargnoli, Kathy A. Johnston, Haiying Zhang, Mark P. Fereshteh, T. G. Murali Dhar, Phil S. Baran   +9 more
doaj   +1 more source

Drosophila Optimization Algorithm Based on Chaotic Development Mechanism and Orthogonal Learning Strategy for Reservoir Optimization. [PDF]

Biomimetics (Basel)
Lv R, Lei G, Liu H, Sun Y, Wang W, Du X.
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

An optimization method for flexible interconnection planning based on improved CNN-LSTM prediction and tunable relative entropy-driven chaotic evolution. [PDF]

PLoS One
Zhao X, Xing X, Guo X, Chao J, Hu D, Zhuan X.   +5 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Research on optimization of train routing problem for railway hubs considering passenger demand. [PDF]

PLoS One
Wang Y.
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Shape optimization of a rubber bumper by using Ansys optiSlang

This thesis aimed to explore the application of optimization algorithms, through the shape optimization of a rubber bumper, a crucial component in automotive engineering.
Platonov, Iurii
core  

Well-posedness and scalarization in vector optimization [PDF]

In this paper we study several existing notions of well-posedness for vector optimization problems. We distinguish them into two classes and we establish the hierarchical structure of their relationships.
Rocca Matteo, Miglierina Enrico, Molho Elena   +2 more
core  

The Quantum Optimization Benchmarking Library. [PDF]

Nat Comput Sci
Koch T, Bernal Neira DE, Chen Y, Cortiana G, Egger DJ, Heese R, Hegade NN, Gomez Cadavid A, Huang R, Itoko T, Kleinert T, Maciel Xavier P, Mohseni N, Montanez-Barrera JA, Nakano K, Nannicini G, O'Meara C, Pauckert J, Proissl M, Ramesh A, Schicker M, Shimada N, Takeori M, Valls V, Van Bulck D, Woerner S, Zoufal C.   +26 more
europepmc   +1 more source