Results 81 to 90 of about 3,171,504 (308)
Optimization for recipe-based, diet-planning inventory management [PDF]
, 2010 Thesis (S.M.)--Massachusetts Institute of Technology, Computation for Design and Optimization Program, 2010.Cataloged from PDF version of thesis.Includes bibliographical references (p.
Kang, Sheng
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Empipe3D™ User’s Manual Version 4.0 -- PC
, 1997 Empipe3D is a powerful and friendly software system for automated electromagnetic (EM) design optimization, driving the 3D field solvers Ansoft HFSS and HP HFSS.
Bandler, John W. +3 more
core +2 more sources
Optimizing Bayesian optimization
, 2018 We are concerned primarily with improving the practical applicability of Bayesian optimization. We make contributions in three key areas. We develop an intuitive online stopping criterion, allowing only as many steps as necessary to achieve the desired target to be taken. By combining this with intelligent online switching between acquisition functions
openaire +3 more sources
Measuring the Optimality of Hadoop Optimization
CoRR, 2013 In recent years, much research has focused on how to optimize Hadoop jobs. Their approaches are diverse, ranging from improving HDFS and Hadoop job scheduler to optimizing parameters in Hadoop configurations. Despite their success in improving the performance of Hadoop jobs, however, very little is known about the limit of their optimization ...
Woo-Cheol Kim +2 more
openaire +2 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Scientific ReportsHepatitis C virus (HCV) infection poses a significant public health challenge and often leads to long-term health complications and even death. Parkinson’s disease (PD) is a progressive neurodegenerative disorder with a proposed viral etiology.
Isis Narváez-Bandera +6 more
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source