Results 181 to 190 of about 3,171,504 (308)

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Bayesian optimization for enzyme-catalyzed, site-selective acetylation of carbohydrate OH groups. [PDF]

Chem Sci
Ruzicka KH, Zambri MT, Reid JP, Taylor MS.   +3 more
europepmc   +1 more source

Well-posed Vector Optimization Problems and Vector Variational Inequalities [PDF]

In this paper we introduce notions of well-posedness for a vector optimization problem and for a vector variational inequality of differential type, we study their basic properties and we establish the links among them.
Rocca Matteo
core  

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

A virtual physicist framework integrating dose prediction and large language models for automated treatment planning. [PDF]

J Appl Clin Med Phys
Zhu H, Li J, Liang Y, Li W, Zhang Y, Zhang W, Yang B, Zhou Q.   +7 more
europepmc   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Discrete optimization. proceedings of the Advanced Research Institute on Discrete Optimization and Systems Applications of the Systems Science Panel of NATO and of the Discrete Optimization Symposium, co-sponsored by IBM Canada and SIAM, Banff, Alta. and Vancouver, B.C., Canada, August 1977 /

, 1979
Includes bibliographical references.Print version record.Cover; TOCContents; Part 3: Methodology; Section 1: Surveys; CHChapter 1. Disjunctive programming; CHChapter 2. Methods of nonlinear 0-1 programming; CHChapter 3.
IBM Canada., Society for Industrial and Applied Mathematics., Hammer, P. L.,1936-2006., Korte, B. H.(Bernhard H.),, Discrete Optimization Symposium(1977 :Vancouver, B.C.), Advanced Research Institute on Discrete Optimization and Systems Applications(1977 :Banff, Alta.), North Atlantic Treaty Organization.Systems Science Panel., Johnson, E. L.(Ellis L.)   +7 more
core  

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Dynamic Proton arc therapy for paediatric parameningeal rhabdomyosarcoma. [PDF]

J Appl Clin Med Phys
Handeland AH, Grewal HS, Boer CG, Indelicato DJ, Ytre-Hauge KS, Henjum H, Stokkevåg CH.   +6 more
europepmc   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source