Results 61 to 70 of about 297,344 (218)
Scientific ReportsHepatitis C virus (HCV) infection poses a significant public health challenge and often leads to long-term health complications and even death. Parkinson’s disease (PD) is a progressive neurodegenerative disorder with a proposed viral etiology.
Isis Narváez-Bandera +6 more
doaj +1 more source
Journal of Research of the National Bureau of Standards, 1985 Most research and development projects require the optimization of a system response as a function of several experimental factors. Familiar chemical examples are the maximization of product yield as a function of reaction time and temperature; the maximization of analytical sensitivity of a wet chemical method as a function of reactant concentration ...
openaire +2 more sources
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
IEEE Access, 2020 Frequency domain spectroscopy (FDS) technique is widely applied in the condition assessment of the oil-paper system in power transformers. However, the synergistic effect generated by moisture and temperature on the FDS data cannot be analyzed by the ...
Xianhao Fan +5 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Equating κ Maximum Degrees in Graphs without Short Cycles
Discussiones Mathematicae Graph Theory, 2020 For an integer k at least 2, and a graph G, let fk(G) be the minimum cardinality of a set X of vertices of G such that G − X has either k vertices of maximum degree or order less than k.
Fürst Maximilian +4 more
doaj +1 more source
IEEE Access, 2020 In recent decades, moisture evaluation of transformer oil-immersed cellulose insulation has been widely studied by using the frequency domain spectroscopy (FDS) technique.
Jiefeng Liu +4 more
doaj +1 more source
Optimal Algorithms for Distributed Optimization
CoRR, 2017 In this paper, we study the optimal convergence rate for distributed convex optimization problems in networks. We model the communication restrictions imposed by the network as a set of affine constraints and provide optimal complexity bounds for four different setups, namely: the function $F(\xb) \triangleq \sum_{i=1}^{m}f_i(\xb)$ is strongly convex ...
César A. Uribe +3 more
openaire +3 more sources
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Data-Informed Decomposition for Localized Uncertainty Quantification of Dynamical Systems
Vibration, 2020 Industrial dynamical systems often exhibit multi-scale responses due to material heterogeneity and complex operation conditions. The smallest length-scale of the systems dynamics controls the numerical resolution required to resolve the embedded physics.
Waad Subber +4 more
doaj +1 more source