Results 111 to 120 of about 2,985,285 (303)

A Survey of Methods for Gas-Lift Optimization

Modelling and Simulation in Engineering, 2012
This paper presents a survey of methods and techniques developed for the solution of the continuous gas-lift optimization problem over the last two decades. These range from isolated single-well analysis all the way to real-time multivariate optimization
Kashif Rashid, William Bailey, Benoît Couët   +2 more
doaj   +1 more source

Calculation model for water influx and controlled reserves for CBM wells with high water yield

Petroleum Research, 2018
Compared with conventional gas reservoir, percolation mechanism of coalbed methane (CBM) is completely different, it is remarkably affected by adsorption/desorption performance, pressure variation and coalbed characteristics.
Qing Feng, Han Jia, Zijun Huang, Miao Tian, Jingsong Li, Xiaonan Li   +5 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A Random-Key optimizer for combinatorial optimization [PDF]

Journal of Heuristics
54 pages, 16 figures, 8 ...
Antonio Augusto Chaves, Mauricio G. C. Resende, Martin J. A. Schuetz, John Kyle Brubaker, Helmut G. Katzgraber, Edilson Fernandes de Arruda, Ricardo M. A. Silva   +6 more
openaire   +3 more sources

Empipe3D™ User’s Manual Version 4.0 -- PC

, 1997
Empipe3D is a powerful and friendly software system for automated electromagnetic (EM) design optimization, driving the 3D field solvers Ansoft HFSS and HP HFSS.
Bandler, John W., Biernacki, R.M., Chen, S.H., Optimization Systems Associates   +3 more
core   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Multi-Objective Optimization Technique Based on QUBO and an Ising Machine

IEEE Access
With an increase in the complexity of society, solving multi-objective optimization problems (MOPs) has become crucial. In this study, we introduced a novel method called “quadratic unconstrained binary optimization based on the weighted normal ...
Hiroshi Ikeda, Takashi Yamazaki
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source