Results 41 to 50 of about 2,403,125 (249)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Use of Plackett–Burman Statistical Design to Study Factors Acting on the Nitric Acid Leaching of Rare Earth Elements from Moroccan Phosphogypsum

Journal of Chemistry
This work is an attempt to understand and optimize the rare earth elements leaching from Moroccan phosphogypsum using a nitric acid solution. The Plackett–Burman statistical design was used to identify the statistically significant factors responsible ...
Fatima Asafar, Marouane Amine, Abdelkader Outzourhit, Latifa Bilali, Mehdi Nadifiyine   +4 more
doaj   +1 more source

A Novel Curve Database for Moisture Evaluation of Transformer Oil-Immersed Cellulose Insulation Using FDS and Exponential Decay Model

IEEE Access, 2020
In recent decades, moisture evaluation of transformer oil-immersed cellulose insulation has been widely studied by using the frequency domain spectroscopy (FDS) technique.
Jiefeng Liu, Zixiao Wang, Xianhao Fan, Yiyi Zhang, Jiaqi Wang   +4 more
doaj   +1 more source

Bio-inspired spatially variant photonic crystals for self-collimation and beam-steering applications in the near-infrared spectrum

Scientific Reports, 2021
The self-collimation of light through Photonic Crystals (PCs) due to their optical properties and through a special geometric structure offers a new form of beam steering with highly optical control capabilities for a range of different applications. The
Rudra Gnawali, Andrew Volk, Imad Agha, Tamara E. Payne, Amit Rai, Jimmy Touma   +5 more
doaj   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Data-Informed Decomposition for Localized Uncertainty Quantification of Dynamical Systems

Vibration, 2020
Industrial dynamical systems often exhibit multi-scale responses due to material heterogeneity and complex operation conditions. The smallest length-scale of the systems dynamics controls the numerical resolution required to resolve the embedded physics.
Waad Subber, Sayan Ghosh, Piyush Pandita, Yiming Zhang, Liping Wang   +4 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Economic and Energetic Performance Evaluation of Unreliable Production Lines: An Integrated Analytical Approach

IEEE Access, 2020
The current context is increasingly driving researchers and industry to focus not only on the economic but also on the energetic performance of manufacturing systems.
Yasmine Alaouchiche, Yassine Ouazene, Farouk Yalaoui   +2 more
doaj   +1 more source