Results 101 to 110 of about 2,429,878 (317)

A Random-Key optimizer for combinatorial optimization [PDF]

Journal of Heuristics
54 pages, 16 figures, 8 ...
Antonio Augusto Chaves, Mauricio G. C. Resende, Martin J. A. Schuetz, John Kyle Brubaker, Helmut G. Katzgraber, Edilson Fernandes de Arruda, Ricardo M. A. Silva   +6 more
openaire   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Research on OPF Control of Three-Phase Four-Wire Low-Voltage Distribution Network considering Uncertainty

International Transactions on Electrical Energy Systems
As power systems become more complex and uncertain, low-voltage distribution networks face numerous challenges, including three-phase imbalances caused by asymmetrical loads and distributed energy resources.
Rui Wang, Xiaoqing Bai, Shengquan Huang, Shoupu Wei   +3 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Empipe3D™ User’s Manual Version 4.0 -- PC

, 1997
Empipe3D is a powerful and friendly software system for automated electromagnetic (EM) design optimization, driving the 3D field solvers Ansoft HFSS and HP HFSS.
Bandler, John W., Biernacki, R.M., Chen, S.H., Optimization Systems Associates   +3 more
core  

Learning-based ship design optimization approach

, 2012
With the development of computer applications in ship design, optimization, as a powerful approach, has been widely used in the design and analysis process.
Philip Sayer, Osman Turan, Turan, Osman, Cui, Hao, Sayer, Philip, Hao Cui   +5 more
core   +1 more source

Recent advances in surrogate-based optimization [PDF]

, 2009
The evaluation of aerospace designs is synonymous with the use of long running computationally intensive simulations. This fuels the desire to harness the efficiency of surrogate-based methods in aerospace design optimization.
Alexander I.J. Forrester, Andy J. Keane, Keane, Andy J., Forrester, Alexander I.J.   +3 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

OSA90/hope™ User’s Manual Version 4.0 -- PC

, 1997
OSA90/hope is a general CAD software system offering simulation, modeling, statistical analysis, nominal and yield optimization, and data visualization for linear and nonlinear analog circuits. Its open architecture allows you to create fully optimizable
Bandler, John W., Biernacki, R.M., Chen, S.H., Optimization Systems Associates   +3 more
core