Results 101 to 110 of about 953,075 (309)
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
With the continuous development of industrial automation, diesel engines play an increasingly important role in various types of construction machinery and power generation equipment.
Luchen Lin +5 more
core +1 more source
Robust fluid control of multiclass queuing networks [PDF]
Thesis (S.M.)--Massachusetts Institute of Technology, Computation for Design and Optimization Program, 2006.Includes bibliographical references (p. 89-92).This thesis applies recent advances in the field of robust optimization to the optimal control of ...
Su, Hua, S.M. Massachusetts Institute of Technology
core
Parallel Solution of Robust Nonlinear Model Predictive Control Problems in Batch Crystallization
Representing the uncertainties with a set of scenarios, the optimization problem resulting from a robust nonlinear model predictive control (NMPC) strategy at each sampling instance can be viewed as a large-scale stochastic program.
Yankai Cao +3 more
core +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Partial least squares (PLS) and linear regression methods have been widely utilized for quality-related fault detection in industrial processes recently.
Majed Aljunaid, Hongbo Shi, Yang Tao
doaj +1 more source
For solving the problems of closed-loop optimization on controller parameters of multiple-controller single-output thermal engineering system, this paper proposes a recurrent optimization method that is based on the particle swarm computing and closed ...
Lei Pan, Xingjian Liu
core +1 more source
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Launcher attitude control: some additional design and optimization tools [PDF]
This paper deals with the launcher attitude control during atmospheric flight. A two step approach combining an H1 control design and an optimization procedure is proposed.
Clément, Benoît +3 more
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