Results 151 to 160 of about 953,075 (309)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

Stochastic impulse control with discounted and ergodic optimization criteria: A comparative study for the control of risky holdings [PDF]

open access: yes
We consider a single-asset investment fund that in the absence of transactions costs would hold a constant amount of wealth in the risky asset. In the presence of market frictions wealth is allowed to fluctuate within a control band: Its upper (lower ...
Yiannis Kamarianakis   +1 more
core  

Control and Optimization of Batch Processes

open access: yes
A batch process is characterized by the repetition of time-varying operations of finite duration. Due to the repetition, there are two independent “time” variables, namely, the run time during a batch and the batch counter.
Bonvin, Dominique
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Duality in $H^infty$ Cone Optimization

open access: yes, 2002
Positive real cones in the space $H^infty$ appear naturally in many optimization problems of control theory and signal processing. Although such problems can be solved by finite-dimensional approximations (e.g., Ritz projection), all such approximations ...
Ghulchak, Andrey   +4 more
core   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

open access: yesMolecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David   +12 more
wiley   +1 more source

Optimizer Algorithms for Supervisory Control : Enabling Supervisor Input:(SUPEROPT D2) [PDF]

open access: yes, 2012
This document reports the methods developed by the SUPEROPT project for supervisor interaction with optimizers. Two mathematical forms for an optimizer to support a Multi-Sector Controller are presented and compared, including various constraint forms to
Richards, Arthur G, Turnbull, Oliver D N
core  

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