Results 51 to 60 of about 7,281,989 (279)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Applications of topology optimization techniques in seismic design of structure
, 2012 During the last two decades, topology optimization techniques have been successfully applied to a wide range of problems including seismic design of structures.
Ghabraie, Kazem
core +1 more source
Optimising the laser-welded butt-joints of medium carbon steel using RSM [PDF]
, 2005 The optimization capabilities in design-expert software were used to optimise the keyhole parameters (i.e. maximize penetration (P) and minimise the heat input, width of welded zone, (W) and width of heat affected zone (WHAZ)) in CW CO2 laser butt ...
Olabi, Abdul-Ghani +2 more
core +2 more sources
e-Prime: Advances in Electrical Engineering, Electronics and Energy, 2023 The capability to supply reliable and efficient electric power is essential for any healthy power distribution network. Achieving these desirable network performance criteria has always been a concern for electric power utility firms.
Bratati Ghosh +2 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Expert System for Structural Optimization Exploiting Past Experience and A-priori Knowledge. [PDF]
, 1994 The availability of comprehensive Structural Optimization Systems in the market is allowing designers direct access to software tools previously the domain of the specialist.
Kuntjoro, Wahyu
core +4 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Energies, 2020 Manta Ray Foraging Optimization Algorithm (MRFO) is a new bio-inspired, meta-heuristic algorithm. MRFO algorithm has been used for the first time to optimize a multi-objective problem. The best size and location of distributed generations (DG) units have
Mahmoud G. Hemeida +4 more
doaj +1 more source