Results 81 to 90 of about 7,281,989 (279)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Optimum Coordination Approach for Directional Overcurrent Relays in Interconnected Power Systems Considering Uncertainty in Photovoltaic Generation

IEEE Access
Optimizing the sensitivity and speed of the overcurrent protection system in the presence of distributed generation units while also ensuring the cost-effective design of the fault current limiter (FCL) represents great challenges for engineers.
Mahmoud A. Elsadd, Hossam A. Abd El-Ghany, Mohamed S. Zaky, Almoataz Y. Abdelaziz, Eman S. Ahmed   +4 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

ExPSO-DL: An Exponential Particle Swarm Optimization Package for Deep Learning Model Optimization

Journal of Open Research Software
This paper presents ExPSO, a Python package designed to simplify parameter selection in deep learning models. ExPSO utilizes the Exponential Particle Swarm Optimization (ExPSO) method for global optimization problems, which has a superior ability to ...
Insaf Kraidia, Khelil Kassoul, Naoufel Cheikhrouhou, Saima Hassan, Samir Brahim Belhaouari   +4 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Optimization of cloud resource demand forecasting and investment decisions in the context of digital transformation

Frontiers in Communications and Networks
With the rapid advancement of digital transformation, enterprises face escalating challenges in cloud resource allocation due to dynamic workloads and substantial capital investments.
Zhuolin Chen, Yuanchun Tang, Fei Wu, Xujing Wang, Minghui Xia, Ziren Wang   +5 more
doaj   +1 more source

Optimization of RHA and Cement proportion for soil stabilization [PDF]

E3S Web of Conferences
The process of changing a soil’s physical characteristics to provide it long-term, permanent improvements in strength is known as soil stabilisation. Increasing a soil’s overall bearing capacity and shear strength is how stabilisation is achieved.
Raman Ravi Shankar, Lavanya C., V Revathi, Nijhawan Ginni, Yadav Dinesh Kumar, Mohammad Q., Arora Sethi Vandana   +6 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Flexible Load Management in Virtual Power Plants: Research Advances, Challenges, and Outlooks

IEEE Access
With the growing penetration of renewable energy sources (RES), intermittency and uncertainty are introduced that challenge grid stability and market operations.
Mazen Mohamed, Slman Mohammed, Md Shafiullah, Nezar M. Al-Yazidi, Md Ismail Hossain, Mohammad A. Abido   +5 more
doaj   +1 more source