Results 121 to 130 of about 2,214,755 (298)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Heuristic Methods of Integer Programming and Its Applications in Economics

Ekonomski Vjesnik, 2010
A short overview of the results related to integer programming is described in the introductory part of this paper. Furthermore, there is a list of literature related to this field.
Dominika Crnjac Milić, Ljiljanka Kvesić   +1 more
doaj  

Efficiences idéales et défaillances réelles : une lecture des Lettres persanes

Etudes Epistémè
In the Lettres persanes, Montesquieu gave a striking formulation of the optimum in political philosophy, according to which the 'most perfect government is the one that reaches its goal at the lowest cost' (Letter LXXX).
Colas Duflo
doaj   +1 more source

Climate change and optimum population [PDF]

Overpopulation is often identified as one of the key drivers of climate change. Further, it is often thought that the mechanism behind this is obvious: 'more people means more greenhouse gas emissions'.
Greaves, Hilary
core  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Optimum and suboptimum frequency demodulation [PDF]

Optimum and suboptimum linear demodulators for telemetry communication ...
Lindsey, W. C.
core   +1 more source

Optimum Experimental Designs

Journal of the Royal Statistical Society Series B: Statistical Methodology, 1959
Summary After some introductory remarks, we discuss certain basic considerations such as the nonoptimality of the classical symmetric (balanced) designs for hypothesis testing, the optimality of designs invariant under an appropriate group of transformations, etc. In section 3 we discuss complete classes of designs, while in section 4 we
openaire   +3 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Investigation of the role of exogenous use of sucrose as an osmoprotectant in increasing Azolla filiculoides resistance to air high temperature and salt stress

‬‭Majallah-i ̒Ilmī-i Shīlāt-i Īrān, 2008
Influence of 2.75 to 11 moles sucrose as an exogenous osmoprotectant on salt stressed (7.8-9.1 and 18.2 ms/cm) and temperature stressed (42.36C) Azolla (A. filiculoides Lam.) was studied.
M. Asfia; A. Ghalavand; H. Heidari; Sh. Nezami; Gh. Normohammadi
doaj  

Optimum maneuvers of hypervelocity vehicles [PDF]

Optimum maneuvering of glide vehicle at hypersonic ...
Busemann, A., Kelley, G. F., Vinh, N. X.
core   +1 more source