Results 181 to 190 of about 2,214,755 (298)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Is there an optimum level of population? [PDF]

Science, 1969
openaire   +2 more sources

Non-destructive assessment of lime and nano-alumina oxide stabilized clay for new material development. [PDF]

Sci Rep
Fahimi R, Soleimani Kutanaei S, Seyedkazemi A, Motaghedi H, Banihashemi M.   +4 more
europepmc   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

The patterns of acetylcholinesterases during developmental stages of Aedes aegypti and their susceptibility toward insecticides in egg stage. [PDF]

Sci Rep
Mohamed SA, Abdel-Aty AM, Al-Talhi HA, Abo-Khatwa AN, Al-Ghamdi KM.   +4 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Optimum City Size: Fact or Fancy? [PDF]

, 1979
Getz, Malcolm
core   +1 more source

Optimization of scours downstream of conduit aerators. [PDF]

Sci Rep
Arici E, Tuna MC, Aytac A, Acar R, Tunc M.   +4 more
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Multi-Scale Performance Assessment of Asphalt Mixtures Modified with Waste PVC Foils of Varying Geometries. [PDF]

Polymers (Basel)
Kırbaş U, İskender E, Kütük-Sert T, Hayat F, Kütük S.   +4 more
europepmc   +1 more source