Results 141 to 150 of about 1,140,649 (309)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Drill Tool Design Based on Fatigue Failure of BHA in S-shaped Well
Shiyou jixie, 2016 Wellbore curvature can cause fatigue damage to BHA in the S-shaped complex trajectory borehole, which could seriously impact the life of drilling tools. In view of this, BHA in the S-shaped wellbore has been mechanically analyzed.
Xu Xiaofeng, Chen Gengxu, Liu Yonghui
doaj
Optimum structural design based on reliability and proof-load testing [PDF]
Proof-load test eliminates structures with strength less than the proof load and improves the reliability value in analysis. It truncates the distribution function of strength at the proof load, thereby alleviating verification of a fitted distribution ...
Shinozuka, M., Yang, J. N.
core +3 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Optimum Safe Hydraulic Design of Culverts
Journal of Engineering and Sustainable Development, 2008 This research aims at obtaining the "Optimum safe hydraulic design of culverts", taking into consideration the cost of excavation, bedding, material, compacted fill, hunches, protection works, and additionally involved head loss.Because of numerous ...
Abdul-Hadi A. Al-Delewy +2 more
doaj
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Optimum Design of Cylindrical Worm Drive
Jixie chuandong, 2016 Taking a cylindrical worm drive mechanism as the research object,the minimizing the volume of worm gear as objective function,the limit of the worm gear tooth surface contact strength,worm stiffness,number of worm threads,worm gear module and worm ...
Wang Yuandong
doaj
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source