Results 141 to 150 of about 16,578,662 (358)
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Traction drive system design considerations for a lunar roving vehicle [PDF]
Optimum design considerations of traction drive for lunar roving ...
Doran, B. J. +2 more
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Drill Tool Design Based on Fatigue Failure of BHA in S-shaped Well
Shiyou jixie, 2016 Wellbore curvature can cause fatigue damage to BHA in the S-shaped complex trajectory borehole, which could seriously impact the life of drilling tools. In view of this, BHA in the S-shaped wellbore has been mechanically analyzed.
Xu Xiaofeng, Chen Gengxu, Liu Yonghui
doaj
Hangkong gongcheng jinzhanAeronautical electronic equipment, used for data collection during flight, is usually fixed to the nose radome using mounting brackets. The stiffness and first-order frequency performance of the mounting brackets is studied to avoid plastic deformation ...
LIU Jia +4 more
doaj +1 more source
Quasi-optimum design of control systems for moving base simulators [PDF]
Optimal control of six degree of freedom moving-base ...
Friedland, B., Ling, C. K.
core +1 more source
The ADS general-purpose optimization program [PDF]
, 1984 The mathematical statement of the general nonlinear optimization problem is given as follows: find the vector of design variables, X, that will minimize f(X) subject to G sub J (x) + or - 0 j=1,m H sub K hk(X) = 0 k=1,l X Lower I approx less than X sub I
Vanderplaats, G. N.
core +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source