Results 161 to 170 of about 16,578,662 (358)
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Optimum structural design based on reliability and proof-load testing [PDF]
Proof-load test eliminates structures with strength less than the proof load and improves the reliability value in analysis. It truncates the distribution function of strength at the proof load, thereby alleviating verification of a fitted distribution ...
Shinozuka, M., Yang, J. N.
core +3 more sources
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Optimum subsonic, high-angle-of-attack nacelles [PDF]
The optimum design of nacelles that operate over a wide range of aerodynamic conditions and their inlets is described. For low speed operation the optimum internal surface velocity distributions and skin friction distributions are described for three ...
Diedrich, J. H. +2 more
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Optimum Tail Plane Design for Sailplanes [PDF]
Classical drag equations in a modern version were used to calculate the influence of tail modifications on the drag of a standard class sailplane. The profile drag which depends on the Reynolds number is included in the calculations.
Mayland, K.
core +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Optimum Design and Application Research of Eddy Current Sensor for Measurement of TBM Disc Cutter Wear. [PDF]
Sensors (Basel), 2019 Wang F, Men C, Kong X, Meng L.
europepmc +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source