Results 51 to 60 of about 1,183,314 (189)
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Valuing Guaranteed Minimum Death Benefits by Cosine Series Expansion
Mathematics, 2019 Recently, the valuation of variable annuity products has become a hot topic in actuarial science. In this paper, we use the Fourier cosine series expansion (COS) method to value the guaranteed minimum death benefit (GMDB) products.
Wenguang Yu +5 more
doaj +1 more source
Ligand recognition by 14‐3‐3 proteins requires negative charges but not necessarily phosphorylation
FEBS Letters, Volume 599, Issue 6, Page 838-847, March 2025.Interactions of 14‐3‐3 proteins with their binding partners are attributed to phosphorylation of the binding partners. In this work, we show that at least one negative charge is required for the peptides to bind 14‐3‐3ε, although phosphorylation is not necessary, and that two negative charges are preferable for high affinity binding.
Seraphine Kamayirese +2 more
wiley +1 more source
Report on "American Option Pricing and Hedging Strategies" [PDF]
arXiv, 2007 This paper mainly discusses the American option's hedging strategies via binomialmodel and the basic idea of pricing and hedging American option. Although the essential scheme of hedging is almost the same as European option, small differences may arise when simulating the process for American option holder has more rights, spelling that the option can
arxiv
Evaluation of Options using the Monte Carlo Method and the Entropy of Information
Expert Journal of Economics, 2018 In the present paper, there are presented, theoretical and applicative, two issues: the evaluation of the European options using the Monte Carlo method and the measurement of the entropy of information for the price of the underlying asset of the option.
Vasile BRĂTIAN
doaj
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Disentangling Options with Hellinger Distance Regularizer [PDF]
arXiv, 2019 In reinforcement learning (RL), temporal abstraction still remains as an important and unsolved problem. The options framework provided clues to temporal abstraction in the RL, and the option-critic architecture elegantly solved the two problems of finding options and learning RL agents in an end-to-end manner.
arxiv
Customization Management Study of Aircraft Based on Product Structure Theory
Hangkong gongcheng jinzhan, 2020 Airline has different demands for market choose, brand construction, flight course and equipment selection, which leads a lot of diversity configuration for different aircraft or different block of aircraft, so the flexibility and high efficiency ...
XU Songlin, ZHOU Jian
doaj +1 more source
FEBS Letters, Volume 599, Issue 7, Page 1055-1074, April 2025.Hermansky‐Pudlak syndrome type 1 (HPS‐1) is a rare, autosomal recessive disorder with poorly understood renal involvement. Urinary extracellular vesicle (uEV) proteomics and a novel Hps1 mouse model reveal mitochondrial abnormalities and lipid accumulation in HPS‐1 kidney proximal tubule cells. Serum ApoA1 correlates with kidney function in our patient
Dawn M. Maynard +7 more
wiley +1 more source
ON ISSUE OF EQUIPPING WATER METERING POINTS WITH TELEMETRY
Научный журнал Российского НИИ проблем мелиорации, 2020 Purpose: choosing the best option for equipping water metering points with telemetry based on information and simulation models of the functioning of these water metering points using the target function. Materials and methods: the studies are based on
A. P. Vasilchenko +2 more
doaj +1 more source