Results 61 to 70 of about 1,183,314 (189)
FEBS Letters, Volume 599, Issue 7, Page 1075-1085, April 2025.We describe a novel set of Epac‐based FRET‐FLIM biosensors with improved fully cytosolic distribution, achieved without compromising the state‐of‐the‐art performance of our original designs, for detecting cAMP dynamics in real time in live cells with high precision and reliability.
Giulia Zanetti +2 more
wiley +1 more source
Learning Diverse Options via InfoMax Termination Critic [PDF]
arXiv, 2020 We consider the problem of autonomously learning reusable temporally extended actions, or options, in reinforcement learning. While options can speed up transfer learning by serving as reusable building blocks, learning reusable options for unknown task distribution remains challenging.
arxiv
Solving barrier options under stochastic volatility using deep learning [PDF]
arXiv, 2022 We develop an unsupervised deep learning method to solve the barrier options under the Bergomi model. The neural networks serve as the approximate option surfaces and are trained to satisfy the PDE as well as the boundary conditions. Two singular terms are added to the neural networks to deal with the non-smooth and discontinuous payoff at the strike ...
arxiv
Asian Option Pricing Based on the Standardized Logarithm of Geometric Average [PDF]
فصلنامه پژوهشهای اقتصادی ایران, 2015 An Asian option (or average value option) is a special type of option contract. Its payoff is determined by the average underlying price over some pre-set period of time. Asian option is hard to price analytically and numerically.
Abdolrahim Badamchizadeh, Narges Heydari
doaj +1 more source
FEBS Letters, Volume 599, Issue 8, Page 1113-1121, April 2025.The glacier ice worm Mesenchytraeus solifugus survives year‐round at 0 °C. Its ATP6 subunit, which forms a regulatory component of the proton pore in mitochondrial ATP synthase, has a carboxy‐terminal extension not found in any other organism examined to date. Here, we show that fusion of this extension to the homologous AtpB protein in E. coli results
Truman Dunkley +2 more
wiley +1 more source
Compositional Planning Using Optimal Option Models [PDF]
arXiv, 2012 In this paper we introduce a framework for option model composition. Option models are temporal abstractions that, like macro-operators in classical planning, jump directly from a start state to an end state. Prior work has focused on constructing option models from primitive actions, by intra-option model learning; or on using option models to ...
arxiv
Functional variation among LPMOs revealed by the inhibitory effects of cyanide and buffer ions
FEBS Letters, Volume 599, Issue 9, Page 1317-1336, May 2025.This study addresses the inhibition of lytic polysaccharide monooxygenases (LPMOs) by cyanide and explains how and why the magnitude of observed inhibitory effects depends on the way LPMO reactions are setup and on the type of LPMO. Enzymes known as lytic polysaccharide monooxygenases (LPMOs) are mono‐copper polysaccharide‐degrading peroxygenases that ...
Ole Golten +10 more
wiley +1 more source
Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases
FEBS Letters, Volume 599, Issue 8, Page 1094-1112, April 2025.The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher +6 more
wiley +1 more source
Core network evolution planning oriented 5G
Dianxin kexue, 2018 Firstly,the 5G standard and industrial progress were summarized,and the 5G core network architecture,key technologies and interworking architecture were combed.On this basis,the idea of phased evolution planning and deployment suggestions for the 5G core
Xu YANG +3 more
doaj
Insertion of the FeB cofactor in cNORs lacking metal inserting chaperones
FEBS Letters, Volume 599, Issue 9, Page 1269-1284, May 2025.Nitric oxide reductase is an enzyme found in the bacterial denitrification pathway. The NOR active site contains a non‐heme iron, often, but not always inserted with the assistance of chaperones. Here, we study the insertion of FeB in the subfamily of cNORs lacking chaperones and found a putative channel, conserved in the family, perhaps enabling the ...
Sofia Appelgren, Pia Ädelroth
wiley +1 more source