Results 101 to 110 of about 5,061,232 (302)

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

open access: yesMolecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti   +10 more
wiley   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

FARM ORGANIZATION OPTIONS [PDF]

open access: yes
This paper is a summary of the management implications to consider when choosing among multiple owner farm business organizations. These include joint operating agreements, partnerships, limited liability companies and corporations, both subchapter C and
Kole, Glenn, Nott, Sherrill B.
core   +1 more source

Expanding Asset-Building: Opportunities Through Shared Ownership [PDF]

open access: yes, 2008
Based on a literature review and interviews, proposes expanding low-income working families' asset-building options beyond individual ownership to shared ownership such as cooperative housing.
Beadsie Woo, Heather McCulloch
core  

The Juridical-Legal Bases of Option Which Is Derived from Breakdown of the Contractual Obligation and Its Functions [PDF]

open access: yesآموزه‌‌های فقه مدني, 2019
One of the issues that have been discussed in jurisprudential and legal books is the option which is resulted from the breakdown of the contract, which Iran’s civil code has also dealt with in the materials (441, 442, 443). In the meantime, the important
Ahmad Mortazi, مهدی صفرخانی
doaj  

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

open access: yesMolecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh   +8 more
wiley   +1 more source

Deep Residual Convolutional Long Short-term Memory Network for Option Price Prediction Problem [PDF]

open access: diamond, 2023
Artur Dossatayev   +2 more
openalex   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

open access: yesMolecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song   +11 more
wiley   +1 more source

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