Results 171 to 180 of about 5,061,232 (302)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Shared decision-making for kidney replacement therapy: a comprehensive review and a proposed model. [PDF]

Korean J Intern Med
Shin HJ, Choi S, Kim S.
europepmc   +1 more source

Gene expression signatures of angiocidin and darapladib treatment connect to therapy options in cervical cancer

, 2012
Martin Koch, Michael D. Wiese
openalex   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

A Cath Lab Disaster: What Can We Do? [PDF]

Methodist Debakey Cardiovasc J
Stukov Y, Gavrylyshin A, Salo S, Levchyshyna OV, Lazoryshynets V, Jacobs JP.   +5 more
europepmc   +1 more source

Direct-to-Consumer Genetic Testing: Failure Is Not an Option

, 2009
Russ B. Altman
openalex   +2 more sources

Anthropogene Klimaveränderung, Sukzessionsprozesse und forstwirtschaftliche Optionen | Anthropogenic Climate Change, Successional Processes and Forest Management Options [PDF]

, 1999
Harald Bugmann
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Deciding on the location for receiving parenteral antimicrobial therapy: development and preliminary testing of a patient decision aid. [PDF]

BMC Health Serv Res
Rasmussen MLT, Stacey D, Lomborg K, Konradsen H.   +3 more
europepmc   +1 more source

The 1995 Farm Bill: Issues, Options, and an Analytical Framework for Integrated Economic and Environmental Policy Assessment

, 1994
Stanley R. Johnson, P. G. Lakshminarayan, Bruce A. Babcock, Andrew Manale, David Zilberman   +4 more
openalex   +1 more source