Results 211 to 220 of about 5,078,605 (303)

Obesity is always a clinically relevant chronic disease. [PDF]

Eat Weight Disord
Donini LM, Ballesteros-Pomar MD, Batsis JA, Boirie Y, Cappellari GG, Poggiogalle E, Barazzoni R.   +6 more
europepmc   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Reducing the environmental impact of medications and improving patient outcomes using the ECO-Rx framework. [PDF]

Can Fam Physician
Hale I, Green S, Nowlan J, Lam I.
europepmc   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

In-Hospital Mortality After Lumbar Fusion is Rare But Occurs Early: A Nationwide Analysis of Risk Factors, 2016-2022. [PDF]

Global Spine J
Ng MK, Mastrokostas LE, Mastrokostas PG, Cristofoli AJ, Xie MW, Baek G, Inzerillo S, Schwartz LB, Singh R, Said M, Meade M, Razi AE, Alvarez AP, Rihn JA, Kurd MF, Kaye ID, Hilibrand AS, Vaccaro AR, Schroeder GD, Kepler CK, Cha TD.   +20 more
europepmc   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Preference versus protocol: oncology clinicians' perspectives on central venous access for administration of chemotherapy in pancreatic cancer. [PDF]

ESMO Gastrointest Oncol
Graus MUJE, Willems RAL, Biesma NC, de Wilde AJ, van den Berkmortel FWPJ, Bouwense SAW, Cirkel GA, Homs MYV, Jellema-Betten E, Pepels-Aarts N, van Santvoort HC, van Vliet ECJ, Wumkes ML, Wilmink JW, de Hingh IHJT, Valkenburg-van Iersel LBJ, de Vos-Geelen J.   +16 more
europepmc   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Promise and pitfalls of AI chatbots in complex decision-making for thyroid nodules and papillary thyroid cancer. [PDF]

Eur Thyroid J
Effraimidis G, Kasotas A, Varsami S, Sazakli E, Karapanou O, Saltiki K, Michalaki M.   +6 more
europepmc   +1 more source