Results 261 to 270 of about 5,203,807 (351)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

The Airway, Breathing, Circulation-Plan, Risk, Options (ABC-PRO) Handover Tool in the PICU: Retrospective Evaluation of Pre- Versus Post-Implementation and Occurrence Rate of Cardiac Arrests, 2020-2023. [PDF]

Pediatr Crit Care Med
De Gaudenzi M, Mozun R, Schlapbach LJ, Kelly-Geyer JF.   +3 more
europepmc   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Trends in Utilization and Cost of Endoscopic Lumbar Decompression in Ambulatory Surgical Centers: A Nationwide Database Analysis From 2018 Through 2022. [PDF]

Global Spine J
Ng MK, Mastrokostas PG, Mastrokostas LE, Lavi AB, Schwartz LB, Eichbaum YK, Lee Y, Hitchner M, Green W, Baek G, Mathew J, Dalton J, Giakas A, Singh R, Razi AE, Kaye ID, Woods B, Kurd MF, Canseco JA, Cha TD, Hilibrand AS, Vaccaro AR, Schroeder GD, Kepler CK.   +23 more
europepmc   +1 more source

Algorithm for solving the problem of a backpack, based on traversing the tree of styling options

, 2014
Georgy Ivanovich Borzunov, Mikhail Andreevich Kupriyashin   +1 more
openalex   +1 more source

Search strings for identifying health-related adaptation metrics, indicators, and outcomes used with mitigation response options

Juel, Rachel
openalex   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Diagnostic criteria and new therapeutic options for patients diagnosed with non-Hodgkin lymphoma

, 2019
Yaimé Moreno-Laguard, Leonardo Laguna-Salvia, José Ignacio Larquin-Comet, Cira Cecilia León-Ramentol, Yadier Fermin Hernandez-Soler, Maurice José González-Basulto   +5 more
openalex   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

External validation of the joint-specific bone involvement, antimicrobial options, coverage of the soft tissues, and host status (JS-BACH) classification for predicting the outcome in periprosthetic joint infections following total hip and knee arthroplasties: a promising tool for clinical practice. [PDF]

J Bone Jt Infect
Schlossmacher B, Lallinger V, Müller D, von Eisenhart-Rothe R, Lazic I.   +4 more
europepmc   +1 more source